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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Rosiglitazone improves endothelial function in patients with type 2 diabetes treated with insulin.

An increased incidence of myocardial infarction with rosiglitazone in patients with type 2 diabetes mellitus (T2DM) has been reported. This study aimed to assess the effect of rosiglitazone on endothelial function, assessed by flow-mediated dilation (FMD), in 34 patients with advanced T2DM treated with insulin without known cardiovascular disease. Patients were randomised into two groups: no additional treatment was given in 17 patients, while 17 patients were given rosiglitazone for 6 months. Addition of rosiglitazone significantly reduced glycosylated haemoglobin (HbA(1c)) (p < 0.0005) and fasting glucose (p < 0.05) and improved FMD (p < 0.005). No significant changes were observed in the insulin-only group. The single independent predictor of FMD improvement was rosiglitazone treatment (p = 0.048). These results show that, in patients with advanced T2DM treated with insulin, addition of rosiglitazone may have a beneficial effect on endothelial function. Further research is needed to investigate why this beneficial effect does not translate into improved cardiovascular prognosis in these patients.[1]

References

  1. Rosiglitazone improves endothelial function in patients with type 2 diabetes treated with insulin. Naka, K.K., Papathanassiou, K., Bechlioulis, A., Pappas, K., Kazakos, N., Kanioglou, C., Papafaklis, M.I., Kostoula, A., Vezyraki, P., Makriyiannis, D., Tsatsoulis, A., Michalis, L.K. Diab. Vasc. Dis. Res (2011) [Pubmed]
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