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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Osmotic regulation of PhoE porin synthesis in Escherichia coli.

In Escherichia coli, adaptation to hyperosmotic conditions alters the expression of the outer membrane porins OmpF and OmpC. The amount of PhoE porin, which is normally induced by phosphate deprivation, was greatly reduced in cells adapted to high-osmolarity conditions. Osmoregulation of PhoE operated independently of the activity of the PhoR phosphate sensor and did not involve cross-talk from the homologous osmosensor EnvZ. PhoE synthesis was partially restored by additional copies of the positive regulator phoB+ and by the osmoprotectant glycine betaine.[1]


  1. Osmotic regulation of PhoE porin synthesis in Escherichia coli. Meyer, S.E., Granett, S., Jung, J.U., Villarejo, M.R. J. Bacteriol. (1990) [Pubmed]
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