Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Doria, A.S. et al.

Andrea S. Doria, Adrian Crawley, Harpal Gahunia, Rahim Moineddin, Tammy Rayner, Vivian Tassos, Anguo Zhong, Kenneth Pritzker, Maria Mendes, Roland Jong, Robert B. Salter,

Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis.

BACKGROUND: Because of the ability of blood-oxygen-level-dependent (BOLD) MRI to assess blood oxygenation changes within the microvasculature, this technique holds potential for evaluating early perisynovial changes in inflammatory arthritis. OBJECTIVE: To evaluate the feasibility of BOLD MRI to detect interval perisynovial changes in knees of rabbits with inflammatory arthritis. MATERIALS AND METHODS: Rabbit knees were injected with albumin (n = 9) or saline (n = 6) intra-articularly, or were not injected (control knees, n = 9). Except for two rabbits (albumin-injected, n = 2 knees; saline-injected, n = 2 knees) that unexpectedly died on days 7 and 21 of the experiment, respectively, all other animals were scanned with BOLD MRI on days 0, 1, 7, 14, 21 and 28 after induction of arthritis. T2*-weighted gradient-echo MRI was performed during alternate 30 s of normoxia/hyperoxia. BOLD MRI measurements were compared with clinical, laboratory and histological markers. RESULTS: Percentage of activated voxels was significantly greater in albumin-injected knees than in contralateral saline-injected knees (P = 0.04). For albumin-injected knees (P < 0.05) and among different categories of knees (P = 0.009), the percentage of activated BOLD voxels varied over time. A quadratic curve for on-and-off BOLD difference was delineated for albumin- and saline-injected knees over time (albumin-injected, P = 0.047; saline-injected, P = 0.009). A trend toward a significant difference in synovial histological scores between albumin-injected and saline-injected knees was noted only for acute scores (P = 0.07). CONCLUSION: As a proof of concept, BOLD MRI can depict perisynovial changes during progression of experimental arthritis.[1]

References

Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis. Doria, A.S., Crawley, A., Gahunia, H., Moineddin, R., Rayner, T., Tassos, V., Zhong, A., Pritzker, K., Mendes, M., Jong, R., Salter, R.B. Pediatr. Radiol (2012) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.