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Chemical Compound Review

Synovial     5-amino-N-butyl-2-prop-2- ynoxy-benzamide

Synonyms: Parsal, Parsalmida, Parsalmide, Parsalmidum, CHEMBL2107094, ...
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Disease relevance of Parsal

  • Here we have synthesised a series of novel substituted benzamides, related to Parsalmide, and have evaluated their activity in vitro on COX-1 and COX-2 as well as in vivo in the carrageenin-induced rat paw edema, a classical in vivo anti-inflammatory assay [1].
  • Parsalmide: a new anti-inflammatory agent Note IX - Toxicological study of parsalmide; oral toxicity study in baboons [2].
  • The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different [3].
  • In the synovial lining from 5 patients with rheumatoid arthritis (RA), all alpha-chains were absent/very weakly stained [4].
  • Our results suggest that synovial fibroblasts may significantly contribute to bone resorption through modulation of RANKL and OPG production in a cytokine-rich milieu of inflamed joints [5].

High impact information on Parsal


Associations of Parsal with other chemical compounds


Gene context of Parsal


  1. Synthesis of substituted benzamides as anti-inflammatory agents that inhibit preferentially cyclooxygenase 1 but do not cause gastric damage. Caliendo, G., Santagada, V., Perissutti, E., Severino, B., Fiorino, F., Warner, T.D., Wallace, J.L., Ifa, D.R., Antunes, E., Cirino, G., de Nucci, G. European journal of medicinal chemistry. (2001) [Pubmed]
  2. Parsalmide: a new anti-inflammatory agent Note IX - Toxicological study of parsalmide; oral toxicity study in baboons. Mazue, G., Berthe, J., Richer, G., Vallee, E. Bollettino chimico farmaceutico. (1976) [Pubmed]
  3. A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model. Zhang, M.C., Mori, S., Date, F., Furukawa, H., Ono, M. Ann. Rheum. Dis. (2007) [Pubmed]
  4. Type IV collagen alpha-chain composition in synovial lining from trauma patients and patients with rheumatoid arthritis. Poduval, P., Sillat, T., Beklen, A., Kouri, V.P., Virtanen, I., Konttinen, Y.T. Arthritis Rheum. (2007) [Pubmed]
  5. Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption. Tunyogi-Csapo, M., Kis-Toth, K., Radacs, M., Farkas, B., Jacobs, J.J., Finnegan, A., Mikecz, K., Glant, T.T. Arthritis Rheum. (2008) [Pubmed]
  6. Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue. Ludikhuize, J., de Launay, D., Groot, D., Smeets, T.J., Vinkenoog, M., Sanders, M.E., Tas, S.W., Tak, P.P., Reedquist, K.A. Arthritis Rheum. (2007) [Pubmed]
  7. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Nakasa, T., Miyaki, S., Okubo, A., Hashimoto, M., Nishida, K., Ochi, M., Asahara, H. Arthritis Rheum. (2008) [Pubmed]
  8. Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor alpha-induced apoptosis. Ahmed, S., Silverman, M.D., Marotte, H., Kwan, K., Matuszczak, N., Koch, A.E. Arthritis Rheum. (2009) [Pubmed]
  9. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. Ospelt, C., Brentano, F., Rengel, Y., Stanczyk, J., Kolling, C., Tak, P.P., Gay, R.E., Gay, S., Kyburz, D. Arthritis Rheum. (2008) [Pubmed]
  10. Expression of mucin 3 and mucin 5AC in arthritic synovial tissue. Volin, M.V., Shahrara, S., Haines, G.K., Woods, J.M., Koch, A.E. Arthritis Rheum. (2008) [Pubmed]
  11. The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: a prospective study. Klaasen, R., Thurlings, R.M., Wijbrandts, C.A., van Kuijk, A.W., Baeten, D., Gerlag, D.M., Tak, P.P. Arthritis Rheum. (2009) [Pubmed]
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