Angiotensin-I-converting enzyme and gallium scan in noninvasive evaluation of sarcoidosis.
Angiotensin-converting enzyme assays and gallium-scan results were obtained from 27 patients with biopsy-proven, clinically active sarcoidosis. Twenty-three of these patients had elevated converting enzyme levels, and 22 had positive gallium-scan results. Three of four patients with normal or borderline-elevated levels of angiotensin-converting enzyme also had positive gallium-scan results. Of 156 nonsarcoid patients (pulmonary and other diseases), 27 were found to have elevated serum converting enzyme levels, and 25 of these had negative gallium-scan results. These results indicate that the combination of an assay of angiotensin-converting enzyme and gallium scan increases diagnostic specificity from 83% to 99% without sacrificing sensitivity. We conclude that the concurrent use of angiotensin-converting enzyme assay and gallium scan is of value in the diagnosis of sarcoidosis.[1]References
- Angiotensin-I-converting enzyme and gallium scan in noninvasive evaluation of sarcoidosis. Nosal, A., Schleissner, L.A., Mishkin, F.S., Lieberman, J. Ann. Intern. Med. (1979) [Pubmed]
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