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Chemical Compound Review

AC1NUW8M     (3S)-3-amino-3-[[(1S)-1- [[(1S)-1-[[(S)...

Synonyms:
 
 
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Disease relevance of Hypertensin

 

High impact information on Hypertensin

 

Chemical compound and disease context of Hypertensin

 

Biological context of Hypertensin

 

Anatomical context of Hypertensin

  • Normal, unstimulated alveolar macrophages (AM) and monocytes (Mo) from both mice and rats have been shown to exhibit an angiotensin-I-forming enzyme [21].
  • The presence of renin and angiotensins and angiotensin-I-converting enzyme in normal macrophages and monocytes seems to be common [21].
  • In this study angiotensin-I-generating activity was measured in bovine aqueous humor and vitreous and in extracts of bovine retina, pigment epithelium-choroid, and anterior uveal tract before and after subjecting these extracts to procedures known to convert prorenin to renin [22].
  • Relationship between serum angiotensin-I-converting enzyme activity and free thyroid hormones: a marker of macrophage activity [23]?
  • Soluble extracts prepared from bovine thymus contain an angiotensin-I-phosphorylating activity that is activated several-fold by high concentrations of NaCl [24].
 

Associations of Hypertensin with other chemical compounds

 

Gene context of Hypertensin

  • The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance--distinct enzymic characteristics and alternative expression during pupal development [30].
  • In contrast, the pressor effect (58 +/- 6 mmHg) of angiotensin-I (300 ng/kg i.v.) was unaffected by the ECE-1 inhibitor (10 mg/kg i.v.) indicating the absence of activity against angiotensin-converting enzyme [31].
  • Apolipoprotein E4, lipoprotein lipase C447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness of carotid and femoral arteries in healthy subjects from the Stanislas cohort [32].
  • The clinical value of inhibition of the renin-angiotensin-aldosterone-system (RAAS) in heart failure has clearly been documented for the ACE-inhibitors as well as for the angiotensin-I-receptor blocker (AT1) by extensive intervention studies (AIRE, CONSENSUS, SAVE, ELITE II, ValHeFT and others) [33].
  • Plasma renin activity and angiotensin-I values were not significantly changed for any of the treatment groups [34].
 

Analytical, diagnostic and therapeutic context of Hypertensin

References

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  2. Angiotensin-I converting enzyme genotypes and left ventricular hypertrophy in patients with hypertrophic cardiomyopathy. Lechin, M., Quiñones, M.A., Omran, A., Hill, R., Yu, Q.T., Rakowski, H., Wigle, D., Liew, C.C., Sole, M., Roberts, R. Circulation (1995) [Pubmed]
  3. Insertion/deletion polymorphism in the angiotensin-I-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy. Tarnow, L., Cambien, F., Rossing, P., Nielsen, F.S., Hansen, B.V., Lecerf, L., Poirier, O., Danilov, S., Boelskifte, S., Borch-Johnsen, K. Diabetologia (1995) [Pubmed]
  4. Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study. Hadjadj, S., Belloum, R., Bouhanick, B., Gallois, Y., Guilloteau, G., Chatellier, G., Alhenc-Gelas, F., Marre, M. J. Am. Soc. Nephrol. (2001) [Pubmed]
  5. Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study. Marian, A.J., Safavi, F., Ferlic, L., Dunn, J.K., Gotto, A.M., Ballantyne, C.M. J. Am. Coll. Cardiol. (2000) [Pubmed]
  6. Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction. Studer, R., Reinecke, H., Müller, B., Holtz, J., Just, H., Drexler, H. J. Clin. Invest. (1994) [Pubmed]
  7. Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial. Meurice, T., Bauters, C., Hermant, X., Codron, V., VanBelle, E., Mc Fadden, E.P., Lablanche, J., Bertrand, M.E., Amouyel, P. Lancet (2001) [Pubmed]
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  9. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects. Ng, D.P., Tai, B.C., Koh, D., Tan, K.W., Chia, K.S. Diabetologia (2005) [Pubmed]
  10. Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice. Hubert, C., Gasc, J.M., Berger, S., Schütz, G., Corvol, P. Mol. Endocrinol. (1999) [Pubmed]
  11. Submaximal endurance exercise performance during enalapril treatment in patients with essential hypertension. van Baak, M.A., Mooij, J.M., Wijnen, J.A., Tan, F.S. Clin. Pharmacol. Ther. (1991) [Pubmed]
  12. Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease. Fukazawa, R., Sonobe, T., Hamamoto, K., Hamaoka, K., Sakata, K., Asano, T., Imai, T., Kamisago, M., Ohkubo, T., Uchikoba, Y., Ikegami, E., Watanabe, M., Ogawa, S. Pediatr. Res. (2004) [Pubmed]
  13. Effects of the angiotensin-I converting enzyme inhibitor perindopril on tumor growth and angiogenesis in head and neck squamous cell carcinoma cells. Yasumatsu, R., Nakashima, T., Masuda, M., Ito, A., Kuratomi, Y., Nakagawa, T., Komune, S. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  14. Relationships between hemodynamic alterations and Child-Pugh Score in patients with cirrhosis. Dincer, D., Besisk, F., Demirkol, O., Demir, K., Kaymakoglu, S., Cakaloglu, Y., Okten, A. Hepatogastroenterology (2005) [Pubmed]
  15. Effect of the angiotensin converting enzyme inhibitor, captopril, on proteinuria in chronic glomerular disease. Masunaga, Y., Tabei, K., Takeda, S., Ando, Y., Kusano, E., Asano, Y. Nippon Jinzo Gakkai shi. (1993) [Pubmed]
  16. Serum angiotensin-I-converting enzyme activity in women with cardiological syndrome X: relation to blood pressure and lipid and carbohydrate metabolic risk markers for coronary heart disease. Proudler, A.J., Crook, D., Godsland, I.F., Collins, P., Rosano, G.M., Stevenson, J.C. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  17. Acute hypertension in a nonhuman primate: humoral and hemodynamic mechanisms. Cody, R.J., Rodger, R.F., Hartley, L.H., Burton, J., Herd, J.A. Hypertension (1982) [Pubmed]
  18. Angiotensin-I converting enzyme genotype-dependent benefit from hormone replacement therapy in isometric muscle strength and bone mineral density. Woods, D., Onambele, G., Woledge, R., Skelton, D., Bruce, S., Humphries, S.E., Montgomery, H. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  19. Molecular biology and genetics of the angiotensin-I-converting enzyme: potential implications in cardiovascular diseases. Villard, E., Soubrier, F. Cardiovasc. Res. (1996) [Pubmed]
  20. Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. Chatelain, R.E., Ghai, R.D., Trapani, A.J., Odorico, L.M., Dardik, B.N., De Lombaert, S., Lappe, R.W., Fink, C.A. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  21. Identification of renin in resident alveolar macrophages and monocytes: HPLC and immunohistochemical study. Dezsö, B., Nielsen, A.H., Poulsen, K. J. Cell. Sci. (1988) [Pubmed]
  22. Identification and quantification of renin and prorenin in the bovine eye. Deinum, J., Derkx, F.H., Danser, A.H., Schalekamp, M.A. Endocrinology (1990) [Pubmed]
  23. Relationship between serum angiotensin-I-converting enzyme activity and free thyroid hormones: a marker of macrophage activity? Kuyl, J.M., Van der Walt, L.A. Clin. Chem. (1986) [Pubmed]
  24. Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Wang, Q.M., Srinivas, P.R., Harrison, M.L., Geahlen, R.L. Biochem. J. (1991) [Pubmed]
  25. Deleterious effect of exogenous angiotensin-I on the extent of regional ischaemia and its inhibition by captopril. Rump, A.F., Rösen, R., Korth, A., Klaus, W. Eur. Heart J. (1993) [Pubmed]
  26. Clinical pharmacokinetics of vasodilators. Part I. Kirsten, R., Nelson, K., Kirsten, D., Heintz, B. Clinical pharmacokinetics. (1998) [Pubmed]
  27. Purification and characterization of two soluble Cl(-)-activated arginyl aminopeptidases from human brain and their endopeptidase action on neuropeptides. McDermott, J.R., Mantle, D., Lauffart, B., Gibson, A.M., Biggins, J.A. J. Neurochem. (1988) [Pubmed]
  28. Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of caco-2 cells. Ogawa, N., Satsu, H., Watanabe, H., Fukaya, M., Tsukamoto, Y., Miyamoto, Y., Shimizu, M. J. Nutr. (2000) [Pubmed]
  29. Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients. Hirakata, H., Onoyama, K., Hori, K., Fujishima, M. Clin. Nephrol. (1986) [Pubmed]
  30. The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance--distinct enzymic characteristics and alternative expression during pupal development. Houard, X., Williams, T.A., Michaud, A., Dani, P., Isaac, R.E., Shirras, A.D., Coates, D., Corvol, P. Eur. J. Biochem. (1998) [Pubmed]
  31. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. Trapani, A.J., Beil, M.E., Bruseo, C.W., De Lombaert, S., Jeng, A.Y. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  32. Apolipoprotein E4, lipoprotein lipase C447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness of carotid and femoral arteries in healthy subjects from the Stanislas cohort. Sass, C., Zannad, F., Herbeth, B., Salah, D., Chapet, O., Siest, G., Visvikis, S. Atherosclerosis (1998) [Pubmed]
  33. Clinical studies on the blockade of the renin-angiotensin-aldosterone-system. Hennig, L. Clin. Nephrol. (2003) [Pubmed]
  34. Angiotensin converting enzyme system in the normal canine eye: pharmacological and physiological aspects. Abrams, K.L., Brooks, D.E., Laratta, L.J., Barnhill, M.A., Frazier, D. Journal of ocular pharmacology. (1991) [Pubmed]
  35. Colorimetry of angiotensin-I converting enzyme activity in serum. Kasahara, Y., Ashihara, Y. Clin. Chem. (1981) [Pubmed]
  36. Adaptation of the plasma renin radioimmunoassay for use with HIV-1 protease. Hyland, L.J., Meek, T.D. Anal. Biochem. (1991) [Pubmed]
  37. Altered interstitial fluid space dynamics and postresuscitation hypertension. Dawson, C.W., Lucas, C.E., Ledgerwood, A.M. Archives of surgery (Chicago, Ill. : 1960) (1981) [Pubmed]
  38. The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography. (The Ludwigshafen Risk and Cardiovascular Health Study). Grammer, T.B., Renner, W., von Karger, S., Boehm, B.O., Winkelmann, B.R., Maerz, W. Mol. Genet. Metab. (2006) [Pubmed]
  39. Alterations of serum carboxypeptidases N and angiotensin-I-converting enzyme in malignant diseases. Schweisfurth, H., Schmidt, M., Brugger, E., Maiwald, L., Thiel, H. Clin. Biochem. (1985) [Pubmed]
 
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