The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound

Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

[search][options]

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Migita, K. et al.

Kiyoshi Migita, Taiichiro Miyashita, Yasumori Izumi, Tomohiro Koga, Atsumasa Komori, Yumi Maeda, Yuka Jiuchi, Yoshihiro Aiba, Satoshi Yamasaki, Atsushi Kawakami, Minoru Nakamura, Hiromi Ishibashi,

Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production.

ABSTRACT: BACKGROUND: The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4+ T cells. RESULTS: CD4+ T cells produced IL-2, IL-4, IL-17, IL-22 and IFN-γ in following stimulation with a CD3 antibody. At the optimal concentration, CP690,550 almost completely inhibited the production of IL-4, IL-17, IL-22 and IFN-γ from these activated CD4+ T cells, but only had marginal effects on IL-2 production. Moreover CP690,550 inhibited anti-CD3-induced phosphorylation of STAT1, STAT3, STAT4, STAT5, and STAT6, but not the TCR-associated phosphorylation of ZAP-70. CONCLUSIONS: Therefore, CP690,550-mediated modification of the JAK/STAT pathway may be a new immunosuppressive strategy in the treatment of autoimmune diseases.[1]

References

Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production. Migita, K., Miyashita, T., Izumi, Y., Koga, T., Komori, A., Maeda, Y., Jiuchi, Y., Aiba, Y., Yamasaki, S., Kawakami, A., Nakamura, M., Ishibashi, H. BMC Immunol. (2011) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg