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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Formation of the lignan, (-) secoisolariciresinol, by cell free extracts of Forsythia intermedia.

A crude cell-free extract from Forsythia intermedia catalyses the formation of (-)secoisolariciresinol, and not its (+) enantiomer, when incubated with coniferyl alcohol in the presence of NAD(P)H and H2O2. This is the first report of an enzyme reaction specifically involved in the coupling reaction between two phenylpropanoid monomers to afford an optically pure lignan.[1]

References

  1. Formation of the lignan, (-) secoisolariciresinol, by cell free extracts of Forsythia intermedia. Umezawa, T., Davin, L.B., Lewis, N.G. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
 
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