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Chemical Compound Review

SureCN177684     4-(3-hydroxyprop-1-enyl)-2- methoxy-phenol

Synonyms: AG-A-66608, AG-F-58462, ACMC-20ale0, Oprea1_201369, CTK1J1518, ...
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Disease relevance of Coniferol

  • The gene loci ehyA and ehyB, which are involved in the bioconversion of eugenol to coniferyl alcohol by Pseudomonas sp. strain HR199 (DSM 7063), were identified as the structural genes of a eugenol hydroxylase that represents an enzyme of the flavocytochrome c class [1].
  • A bacterial isolate identified as Xanthomonas sp. proved to be ligninolytic due to its ability to degrade 14C-labeled dehydropolymers of coniferyl alcohol (DHP) and [14C]lignocellulose complexes from corn plants (Zea mays) [2].
  • Several Nocardia and Pseudomonas spp., as well as some unidentified bacteria, isolated from lake water containing high loads of waste lignin, were tested for their capacity to release 14CO2 from specifically 14C-labelled dehydropolymer of coniferyl alcohol (DHP) or corn stalk lignins [3].
  • Upon incubation of Rhizobium rhizogenes A4 with coniferyl alcohol, a lignin precursor, bacterial virulence on cotton cotyledon slices was stimulated [4].
  • Coevolutionary toxicity as suggested by differential coniferyl alcohol inhibition of ceratocystis species growth [5].

Psychiatry related information on Coniferol

  • Mn catalysts were found to oxidize coniferyl alcohol in a same reaction time as horseradish peroxidase (HRP) enzyme and Mn and Co catalysts showed different regioselectivity suggesting a different substrate to catalyst interaction in the oxidative coupling [6].

High impact information on Coniferol

  • Provision of increasing levels of exogenously supplied Phe to saturating levels (40 mm) to the induction medium resulted in further up-regulation of their transcript levels in the P. taeda cell cultures; this in turn was accompanied by considerable increases in both p-coumaryl and coniferyl alcohol formation and excretion [7].
  • Petunia flower petals emit large amounts of isoeugenol, which has been shown to be synthesized by isoeugenol synthase (PhIGS1) from an ester of coniferyl alcohol, hypothesized to be coniferyl acetate [8].
  • UV-B exposure preferentially enhanced guaiacol-peroxidases, ascorbate peroxidase, and peroxidases specific to coniferyl alcohol and modified the substrate affinity of ascorbate peroxidase [9].
  • A marked degree of physical interaction was detected between the enzymatic binding sites of the coniferyl alcohol substrate and the 2'-phosphate binding region, which are quite distant in the three-dimensional structure [10].
  • Images generated using the 1,650 cm(-1) band showed that coniferaldehyde and coniferyl alcohol distribution followed that of lignin and no particular cell wall layer/region was therefore enriched in the ethylenic residue [11].

Chemical compound and disease context of Coniferol


Biological context of Coniferol


Anatomical context of Coniferol

  • A diffusion cell was used to allow the diffusion of both hydrogen peroxide and coniferyl alcohol into the peroxidase impregnated cellulose mats through dialysis membranes [18].

Associations of Coniferol with other chemical compounds


Gene context of Coniferol

  • Lignin peroxidase from a white-rot basidiomycete, Phanerochaete chrysosporium, catalyzed cleavages of the aromatic ring and the beta-O-4 bond of a synthetic lignin, a dehydrogenation copolymer (DHP) of coniferyl alcohol and a (beta-O-4)-(beta-beta) lignin substructure model trimer [23].
  • Results also showed that the oxidase activity of this peroxidase is due to an evolutionarily gained optimal adaptation of the enzyme to the microM H(2)O(2) concentrations generated during the auto-oxidation of coniferyl alcohol, the stoichiometry of the chemical reaction (mol coniferyl alcohol auto-oxidized/mol H(2)O(2) formed) being 0.496 [24].
  • We have characterized two H2O2-independent phenoloxidases with approximate molecular masses of 90 kDa and 110 kDa from cell walls of Populus euramericana xylem that are capable of oxidizing coniferyl alcohol [25].
  • The ZPO-C:6xHis protein had a peroxidase activity preferring sinapyl alcohol as well as coniferyl alcohol as a substrate, with a narrow pH optimum around 5.25 [26].
  • When coniferyl alcohol was the unique HRP substrate, three major dimers were observed (beta-5, beta-beta, and beta-O-4 interunit linkages) and their initial formation velocity as well as their relative abundance varied with pH [27].

Analytical, diagnostic and therapeutic context of Coniferol


  1. Identification and molecular characterization of the eugenol hydroxylase genes (ehyA/ehyB) of Pseudomonas sp. strain HR199. Priefert, H., Overhage, J., Steinbüchel, A. Arch. Microbiol. (1999) [Pubmed]
  2. Bacterial degradation of dehydropolymers of coniferyl alcohol. Kern, H.W. Arch. Microbiol. (1984) [Pubmed]
  3. Screening for lignin degrading bacteria by means of 14C-labelled lignins. Haider, K., Trojanowski, J., Sundman, V. Arch. Microbiol. (1978) [Pubmed]
  4. Coniferyl alcohol, a lignin precursor, stimulates Rhizobium rhizogenes A4 virulence. Gafni, Y., Levy, Y. Curr. Microbiol. (2005) [Pubmed]
  5. Coevolutionary toxicity as suggested by differential coniferyl alcohol inhibition of ceratocystis species growth. Daurade-Le Vagueresse, M.H., Romiti, C., Grosclaude, C., Bounias, M. Toxicon (2001) [Pubmed]
  6. Salen complexes with bulky substituents as useful tools for biomimetic phenol oxidation research. Haikarainen, A., Sipilä, J., Pietikäinen, P., Pajunen, A., Mutikainen, I. Bioorg. Med. Chem. (2001) [Pubmed]
  7. Transcriptional control of monolignol biosynthesis in Pinus taeda: factors affecting monolignol ratios and carbon allocation in phenylpropanoid metabolism. Anterola, A.M., Jeon, J.H., Davin, L.B., Lewis, N.G. J. Biol. Chem. (2002) [Pubmed]
  8. Characterization of a petunia acetyltransferase involved in the biosynthesis of the floral volatile isoeugenol. Dexter, R., Qualley, A., Kish, C.M., Ma, C.J., Koeduka, T., Nagegowda, D.A., Dudareva, N., Pichersky, E., Clark, D. Plant J. (2007) [Pubmed]
  9. Ultraviolet-B- and ozone-induced biochemical changes in antioxidant enzymes of Arabidopsis thaliana. Rao, M.V., Paliyath, G., Ormrod, D.P. Plant Physiol. (1996) [Pubmed]
  10. Site-directed mutagenesis of a serine residue in cinnamyl alcohol dehydrogenase, a plant NADPH-dependent dehydrogenase, affects the specificity for the coenzyme. Lauvergeat, V., Kennedy, K., Feuillet, C., McKie, J.H., Gorrichon, L., Baltas, M., Boudet, A.M., Grima-Pettenati, J., Douglas, K.T. Biochemistry (1995) [Pubmed]
  11. Raman imaging to investigate ultrastructure and composition of plant cell walls: distribution of lignin and cellulose in black spruce wood (Picea mariana). Agarwal, U.P. Planta (2006) [Pubmed]
  12. Antiosteoporotic activity of the stems of Sambucus sieboldiana. Li, H., Li, J., Prasain, J.K., Tezuka, Y., Namba, T., Miyahara, T., Tonami, S., Seto, H., Tada, T., Kadota, S. Biol. Pharm. Bull. (1998) [Pubmed]
  13. Enzymic synthesis of lignin precursors. Purification and properties of UDP glucose: coniferyl-alcohol glucosyltransferase from cambial sap of spruce (Picea abies L.). Schmid, G., Grisebach, H. Eur. J. Biochem. (1982) [Pubmed]
  14. Characterization of beta-glucosidase isoenzymes possibly involved in lignification from chick pea (Cicer arietinum L.) cell suspension cultures. Hösel, W., Surholt, E., Borgmann, E. Eur. J. Biochem. (1978) [Pubmed]
  15. Aggregation during coniferyl alcohol polymerization in pectin solution: a biomimetic approach of the first steps of lignification. Lairez, D., Cathala, B., Monties, B., Bedos-Belval, F., Duran, H., Gorrichon, L. Biomacromolecules (2005) [Pubmed]
  16. Consumption and metabolism of 1,2-dimethoxy-4-(3-fluoro-2-propenyl)benzene, a fluorine analog of methyl eugenol, in the oriental fruit fly Bactrocera dorsalis (Hendel). Khrimian, A., Jang, E.B., Nagata, J., Carvalho, L. J. Chem. Ecol. (2006) [Pubmed]
  17. Harnessing eugenol as a substrate for production of aromatic compounds with recombinant strains of Amycolatopsis sp. HR167. Overhage, J., Steinbüchel, A., Priefert, H. J. Biotechnol. (2006) [Pubmed]
  18. Synthesis and characterization of dehydrogenation polymers in Gluconacetobacter xylinus cellulose and cellulose/pectin composite. Touzel, J.P., Chabbert, B., Monties, B., Debeire, P., Cathala, B. J. Agric. Food Chem. (2003) [Pubmed]
  19. Differential accumulation of monolignol-derived compounds in elicited flax (Linum usitatissimum) cell suspension cultures. Hano, C., Addi, M., Bensaddek, L., Crônier, D., Baltora-Rosset, S., Doussot, J., Maury, S., Mesnard, F., Chabbert, B., Hawkins, S., Lainé, E., Lamblin, F. Planta (2006) [Pubmed]
  20. Involvement of AtLAC15 in lignin synthesis in seeds and in root elongation of Arabidopsis. Liang, M., Davis, E., Gardner, D., Cai, X., Wu, Y. Planta (2006) [Pubmed]
  21. Oxidation of coniferyl alcohol by cell wall peroxidases at the expense of indole-3-acetic acid and O2. A model for the lignification of plant cell walls in the absence of H2O2. Ferrer, M.A., Pedreño, M.A., Muñoz, R., Barceló, A.R. FEBS Lett. (1990) [Pubmed]
  22. Cellular machinery of wood production: differentiation of secondary xylem in Pinus contorta var. latifolia. Samuels, A.L., Rensing, K.H., Douglas, C.J., Mansfield, S.D., Dharmawardhana, D.P., Ellis, B.E. Planta (2002) [Pubmed]
  23. Cleavages of aromatic ring and beta-O-4 bond of synthetic lignin (DHP) by lignin peroxidase. Umezawa, T., Higuchi, T. FEBS Lett. (1989) [Pubmed]
  24. H(2)O(2) generation during the auto-oxidation of coniferyl alcohol drives the oxidase activity of a highly conserved class III peroxidase involved in lignin biosynthesis. Pomar, F., Caballero, N., Pedreño, M., Ros Barceló, A. FEBS Lett. (2002) [Pubmed]
  25. Biochemical characterization, molecular cloning and expression of laccases - a divergent gene family - in poplar. Ranocha, P., McDougall, G., Hawkins, S., Sterjiades, R., Borderies, G., Stewart, D., Cabanes-Macheteau, M., Boudet, A.M., Goffner, D. Eur. J. Biochem. (1999) [Pubmed]
  26. Isolation and Characterization of a Novel Peroxidase Gene ZPO-C Whose Expression and Function are Closely Associated with Lignification during Tracheary Element Differentiation. Sato, Y., Demura, T., Yamawaki, K., Inoue, Y., Sato, S., Sugiyama, M., Fukuda, H. Plant Cell Physiol. (2006) [Pubmed]
  27. Initial steps of the peroxidase-catalyzed polymerization of coniferyl alcohol and/or sinapyl aldehyde: capillary zone electrophoresis study of pH effect. Fournand, D., Cathala, B., Lapierre, C. Phytochemistry (2003) [Pubmed]
  28. Progress of lignification mediated by intercellular transportation of monolignols during tracheary element differentiation of isolated Zinnia mesophyll cells. Hosokawa, M., Suzuki, S., Umezawa, T., Sato, Y. Plant Cell Physiol. (2001) [Pubmed]
  29. Enzymatic polymerization of coniferyl alcohol in the presence of cyclodextrins. Nakamura, R., Matsushita, Y., Umemoto, K., Usuki, A., Fukushima, K. Biomacromolecules (2006) [Pubmed]
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