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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chordal replacement in mitral valve repair.

Chordal replacement greatly extends the possibility of repair of atrioventricular valves. Both glutaraldehyde-tanned xenograft pericardial chordae ( GTXP) and extruded polytetrafluorethylene chordae (ePTFE) heal to papillary muscles and cusps. Neither type elongates or shrinks. GTXP may thicken and stiffen with time. ePTFE is covered by a normal fibrosa and intima (a new chorda is grown around the ePTFE suture) experimentally and in small sizes (e.g., CV 5), retains flexibility. The results of late follow-up (5-10 years) with GTXP chordae and early follow-up (6-58 months) with ePTFE chordae are encouraging.[1]


  1. Chordal replacement in mitral valve repair. Frater, R.W., Vetter, H.O., Zussa, C., Dahm, M. Circulation (1990) [Pubmed]
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