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MeSH Review

Mitral Valve

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Disease relevance of Mitral Valve


Psychiatry related information on Mitral Valve


High impact information on Mitral Valve


Chemical compound and disease context of Mitral Valve


Biological context of Mitral Valve


Anatomical context of Mitral Valve


Associations of Mitral Valve with chemical compounds

  • METHODS: Seven sheep underwent implantation of a new stentless, glutaraldehyde-preserved porcine mitral valve (Physiological Mitral Valve [PMV], Medtronic) and were studied acutely under open-chest conditions [29].
  • On the two-dimensional echocardiograms, the position of coaptation of the mitral valve was shifted closer to the base of the anterior leaflet in the presence of dobutamine-induced SAM than before the drug was administered [30].
  • Echocardiographically determined mitral valve reopening time was established for each coupling interval in the control state as well as under the influence of calcium or verapamil [31].
  • We measured transpulmonary indicator dilution curves of 51Cr-erythrocytes, 125I-albumin, 14C-urea, and 3H-water before and six and 24 hours after operation in seven patients undergoing aortocoronary bypass (ACB) and eight patients undergoing mitral valve replacement (MVR) [21].
  • Six open-chest, fentanyl-anesthetized dogs were instrumented with micromanometers and an electronically controlled mitral valve occluder in series with the electromagnetic flow probe [32].

Gene context of Mitral Valve

  • The role of PLAU genetic variant in mitral valve prolapse (MVP) has not been studied [33].
  • Distribution of CGRP, ChAT, and NPY immunoreactivities, and adrenergic fluorescence, were the same as those of the nerve-related antigens in both normal and prolapsed mitral valves [34].
  • These findings indicated that the tumorous deformity of the mitral valve was formed by the overgrowth of valve tissue under the stimulation of mitral regurgitation in this child, and the imbalance of MMP and TIMP might play an important role in the bulge formation [35].
  • During delamination of the valves, BMP4 and -6 mRNA are expressed at the ventricular side of the forming mitral valve, BMP4 mRNA at the ventricular side of the forming tricuspid valve, and BMP2, -4, and -6 mRNA at the vascular side of the forming semilunar valves [36].
  • RESULTS: After mitral valve replacement, TNF-a, IL-6 and sFas levels, as well as the Vmax LA volume, were significantly reduced (p < 0.05) [37].

Analytical, diagnostic and therapeutic context of Mitral Valve


  1. Decreased myocardial taurine levels and hypertaurinuria in a kindred with mitral-valve prolapse and congestive cardiomyopathy. Darsee, J.R., Heymsfield, S.B. N. Engl. J. Med. (1981) [Pubmed]
  2. Recombinant tissue plasminogen activator for prosthetic mitral-valve thrombosis. Astengo, D., Badano, L., Bertoli, D. N. Engl. J. Med. (1995) [Pubmed]
  3. Does this patient have an abnormal systolic murmur? Etchells, E., Bell, C., Robb, K. JAMA (1997) [Pubmed]
  4. The effect of low-dose intravenous nitroglycerin on pulmonary hypertension immediately after replacement of a stenotic mitral valve. Ziskind, Z., Pohoryles, L., Mohr, R., Smolinsky, A., Quang, H.T., Ruvolo, G., Goor, D.A. Circulation (1985) [Pubmed]
  5. Limitations of the echocardiogram in diagnosing valvular vegetations in patients with mitral valve prolapse. Chandraratna, P.A., Langevin, E. Circulation (1977) [Pubmed]
  6. Effect of sodium lactate on patients with panic disorder and mitral valve prolapse. Gorman, J.M., Fyer, A.F., Gliklich, J., King, D., Klein, D.F. The American journal of psychiatry. (1981) [Pubmed]
  7. Migraine treatment. Young, W.B., Silberstein, S.D., Dayno, J.M. Seminars in neurology. (1997) [Pubmed]
  8. Panic disorder: psychopathology, medical management and dental implications. Friedlander, A.H., Marder, S.R., Sung, E.C., Child, J.S. Journal of the American Dental Association (1939) (2004) [Pubmed]
  9. Changes in the drug treatment of anxiety disorders. Pohl, R., Rainey, J.M., Gershon, S. Psychopathology. (1984) [Pubmed]
  10. The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs. Khan, M.A., Herzog, C.A., St Peter, J.V., Hartley, G.G., Madlon-Kay, R., Dick, C.D., Asinger, R.W., Vessey, J.T. N. Engl. J. Med. (1998) [Pubmed]
  11. Retraction. Darsee JR, Heymsfield SB. Decreased myocardial taurine levels and hypertaurinuria in a kindred with mitral-valve prolapse and congestive cardiomyopathy. N Engl J Med 1981;304:129-35. Heymsfield, S.B., Glenn, J.F. N. Engl. J. Med. (1983) [Pubmed]
  12. Association of mitral-valve prolapse with low body-weight and low blood pressure. Devereux, R.B., Brown, W.T., Lutas, E.M., Kramer-Fox, R., Laragh, J.H. Lancet (1982) [Pubmed]
  13. Letter: Mitral-valve echocardiography in rheumatoid arthritis. Nomeir, A.M., Watts, L.E., Turner, R. Ann. Intern. Med. (1976) [Pubmed]
  14. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Boulter, C., Mulroy, S., Webb, S., Fleming, S., Brindle, K., Sandford, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  15. Comparison of anticoagulation regimens after Carpentier-Edwards aortic or mitral valve replacement. Blair, K.L., Hatton, A.C., White, W.D., Smith, L.R., Lowe, J.E., Wolfe, W.G., Young, W.G., Oldham, H.N., Douglas, J.M., Glower, D.D. Circulation (1994) [Pubmed]
  16. Impact of dual-chamber permanent pacing in patients with obstructive hypertrophic cardiomyopathy with symptoms refractory to verapamil and beta-adrenergic blocker therapy. Fananapazir, L., Cannon, R.O., Tripodi, D., Panza, J.A. Circulation (1992) [Pubmed]
  17. Simultaneous echocardiographic phonocardiographic recordings at rest and during amyl nitrite administration in patients with mitral valve prolapse. Winkle, R.A., Goodman, D.J., Popp, R.L. Circulation (1975) [Pubmed]
  18. Warfarin versus dipyridamole-aspirin and pentoxifylline-aspirin for the prevention of prosthetic heart valve thromboembolism: a prospective randomized clinical trial. Mok, C.K., Boey, J., Wang, R., Chan, T.K., Cheung, K.L., Lee, P.K., Chow, J., Ng, R.P., Tse, T.F. Circulation (1985) [Pubmed]
  19. Analysis of left ventricular function in response to afterload changes in patients with mitral stenosis. Bolen, J.L., Lopes, M.G., Harrison, D.C., Alderman, E.L. Circulation (1975) [Pubmed]
  20. Systemic and pulmonary effects of nitroprusside during mitral valve replacement in patients with mitral regurgitation. Lappas, D.G., Ohtaka, M., Fahmy, N.R., Buckley, M.J. Circulation (1978) [Pubmed]
  21. Lung water and urea indicator dilution studies in cardiac surgery patients. Comparisons of measurements in aortocoronary bypass and mitral valve replacement. Brigham, K.L., Faulkner, S.L., Fisher, R.D., Bender, H.W. Circulation (1976) [Pubmed]
  22. Multiple molecular mechanisms underlying subdiagnostic variants of Marfan syndrome. Montgomery, R.A., Geraghty, M.T., Bull, E., Gelb, B.D., Johnson, M., McIntosh, I., Francomano, C.A., Dietz, H.C. Am. J. Hum. Genet. (1998) [Pubmed]
  23. Mitral valve prolapse with symptoms of beta-adrenergic hypersensitivity. Beta 2-adrenergic receptor supercoupling with desensitization on isoproterenol exposure. Davies, A.O., Mares, A., Pool, J.L., Taylor, A.A. Am. J. Med. (1987) [Pubmed]
  24. Dystrophic degeneration of papillary muscle and ventricular myocardium. A basis for mitral valve prolapse in Duchenne's muscular dystrophy. Sanyal, S.K., Johnson, W.W., Dische, M.R., Pitner, S.E., Beard, C. Circulation (1980) [Pubmed]
  25. Cardiac valvular anomalies in Fabry disease. Clinical, morphologic, and biochemical studies. Desnick, R.J., Blieden, L.C., Sharp, H.L., Hofschire, P.J., Moller, J.H. Circulation (1976) [Pubmed]
  26. Digitalis and the sick sinus syndrome. Clinical and electrophysiologic documentation of severe toxic effect on sinus node function. Margolis, J.R., Strauss, H.C., Miller, H.C., Gilbert, M., Wallace, A.G. Circulation (1975) [Pubmed]
  27. Mitral valve prolapse. Wigle, E.D., Rakowski, H., Ranganathan, N., Silver, M.C. Annu. Rev. Med. (1976) [Pubmed]
  28. Fibronectin biosynthesis and cell-surface expression by cardiac and non-cardiac endothelial cells. Johnson, C.M., Helgeson, S.C. Am. J. Pathol. (1993) [Pubmed]
  29. Functional evaluation of the medtronic stentless porcine xenograft mitral valve in sheep. Dagum, P., Green, G.R., Timek, T.A., Daughters, G.T., Foppiano, L.E., Tye, T.L., Bolger, A.F., Ingels, N.B., Miller, D.C. Circulation (1999) [Pubmed]
  30. Production of systolic anterior motion of the mitral valve in dogs. Sakurai, S., Tanaka, H., Yoshimura, H., Nakao, S., Tahara, M. Circulation (1985) [Pubmed]
  31. Diastolic 'locking' of the mitral valve: possible importance of diastolic myocardial properties. David, D., Michelson, E.L., Naito, M., Chen, C.C., Schaffenburg, M., Dreifus, L.S. Circulation (1986) [Pubmed]
  32. Diastolic viscous properties of the intact canine left ventricle. Nikolic, S.D., Tamura, K., Tamura, T., Dahm, M., Frater, R.W., Yellin, E.L. Circ. Res. (1990) [Pubmed]
  33. Association between urokinase-plasminogen activator gene T4065C polymorphism and risk of mitral valve prolapse. Chou, H.T., Chen, Y.T., Wu, J.Y., Tsai, F.J. International journal of cardiology. (2004) [Pubmed]
  34. Histopathologic studies of innervation of normal and prolapsed human mitral valves. Oki, T., Fukuda, N., Kawano, T., Iuchi, A., Tabata, T., Manabe, K., Kageji, Y., Sasaki, M., Yamada, H., Ito, S. J. Heart Valve Dis. (1995) [Pubmed]
  35. Tumorous deformity of mitral valve leaflet after chordal rupture in a child. Tamura, K., Sugisaki, Y., Ogawa, S., Yamauchi, H., Okada, R. Pathol. Int. (2003) [Pubmed]
  36. Dynamic patterns of expression of BMP isoforms 2, 4, 5, 6, and 7 during chicken heart development. Somi, S., Buffing, A.A., Moorman, A.F., Van Den Hoff, M.J. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2004) [Pubmed]
  37. Left atrial function, cytokines and soluble apoptotic markers in mitral stenosis: effects of valvular replacement. Trikas, A., Papathanasiou, S., Tousoulis, D., Tentolouris, K., Vasiliadou, K., Antoniades, C., Latsios, G., Stefanadis, C. International journal of cardiology. (2005) [Pubmed]
  38. Determination of left ventricular chamber stiffness from the time for deceleration of early left ventricular filling. Little, W.C., Ohno, M., Kitzman, D.W., Thomas, J.D., Cheng, C.P. Circulation (1995) [Pubmed]
  39. Left ventricular filling in hypertrophic cardiomyopathy: a pulsed Doppler echocardiographic study. Takenaka, K., Dabestani, A., Gardin, J.M., Russell, D., Clark, S., Allfie, A., Henry, W.L. J. Am. Coll. Cardiol. (1986) [Pubmed]
  40. Thallium-201 myocardial perfusion studies in patients with the mitral valve prolapse syndrome. Gaffney, F.A., Wohl, A.J., Blomqvist, C.G., Parkey, R.W., Willerson, J.T. Am. J. Med. (1978) [Pubmed]
  41. Assessment of accuracy of the Doppler pressure half-time method in the estimation of the mitral valve area immediately after balloon mitral valvuloplasty. Pitsavos, C.E., Stefanadis, C.I., Stratos, C.G., Lambrou, S.G., Toutouzas, K.P., Barbetseas, I.D., Toutouzas, P.K. Eur. Heart J. (1997) [Pubmed]
  42. Surgical management of valvular disease in patients requiring left ventricular assist device support. Rao, V., Slater, J.P., Edwards, N.M., Naka, Y., Oz, M.C. Ann. Thorac. Surg. (2001) [Pubmed]
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