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Maeda-Yamamoto, M. et al.

Mari Maeda-Yamamoto, Takeshi Saito, Atsushi Nesumi, Yoshiko Tokuda, Kaori Ema, Daiki Honma, Akiko Ogino, Manami Monobe, Akira Murakami, Akira Murakami, Hirofumi Tachibana,

Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. Sunrouge).

BACKGROUND: The purpose of this study was to evaluate the effects of leaf order or crop season on anthocyanins and other chemicals in the anthocyanin-rich tea cultivar 'Sunrouge' (Camellia sinensis x C. taliensis) by using high-performance liquid chromatography, and to study the effect of 'Sunrouge' extract on acetylcholinesterase (AChE) activity in human neuroblastoma SK-N-SH cells. RESULTS: The total anthocyanin content was higher in the third (3.09 mg g(-1) ) than in the second (2.24 mg g(-1) ) or first crop season (1.79 mg g(-1) ). The amount of anthocyanins contained in the stem was high (1.61 mg g(-1) ). In the third crop season, the concentrations of delphinidin-3-O-β-D-(6-(E)-p-coumaroyl)galactopyranoside (DCGa), cyanidin-3-O-β-D-(6-(E)-p-coumaroyl)galactopyranoside, delphinidin-3-O-β-D-galactopyranoside, delphinidin-3-O-β-D-(6-O-(Z)-p-coumaroyl)galactopyranoside, cyanidin-3-O-β-D-galactoside, and delphinidin-3-O-β-D-glucoside were 1.57 mg g(-1) , 0.52 mg g(-1) , 0.40 mg g(-1) , 0.22 mg g(-1) , 0.14 mg g(-1) , and 0.11 mg g(-1) , respectively. DCGa accounted for about 50% of the anthocyanins present. The suppressive effect of 'Sunrouge' water extract on AChE activity in human neuroblastoma SK-N-SH cells was the strongest among the three tea cultivars ('Sunrouge', 'Yabukita' and 'Benifuuki'). CONCLUSION: These results suggested that 'Sunrouge' might protect humans from humans from AChE-related diseases by suppressing AChE activity. To obtain sufficient amounts of anthocyanins, catechins and/or caffeine for a functional food material, 'Sunrouge' from the third crop season should be used. Copyright © 2012 Society of Chemical Industry.[1]

References

Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. Sunrouge). Maeda-Yamamoto, M., Saito, T., Nesumi, A., Tokuda, Y., Ema, K., Honma, D., Ogino, A., Monobe, M., Murakami, A., Murakami, A., Tachibana, H. J. Sci. Food Agric. (2012) [Pubmed]

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