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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Chemical Industry

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Disease relevance of Chemical Industry


High impact information on Chemical Industry


Biological context of Chemical Industry


Anatomical context of Chemical Industry

  • STUDY DESIGN: A primary fibroblast culture that was developed from a biopsy specimen of the arcus tendineus was treated with interleukin-1 beta (10-15 ng/mL), transforming growth factor-beta 1 (5-15 ng/mL), 17 beta-estradiol (10(-9)-10(-7) mol/L), and Imperial Chemical Industries (ICI) 182 780 (10(-8)-10(-6) mol/L) [14].

Associations of Chemical Industry with chemical compounds


Gene context of Chemical Industry

  • The endothelin-A- and -B- (ETA/ETB) receptor antagonist (TAK-044, Takeda Chemical Industries, Osaka, Japan) was administered subcutaneously at a dose of 10 mg/kg/day from the age of 8 weeks for 4 weeks [20].
  • Ponalrestat ["Statil" (a trademark, the property of Imperical Chemical Industries PLC), "Prodiax" (a trademark, the property of Merck, Sharp and Dohme), ICI 128436, MK538] inhibits ALR2 from a number of sources [21].
  • Both subjects have been addressed by a specific OECD working group (EDTA-Endocrine Disruptor Testing and Assessment Task Force) involving regulatory agencies, the scientific community, chemical industry and NGOs [22].
  • Diabetic rats were either untreated, treated only with either the aldose reductase inhibitor Statil (Imperial Chemical Industries, Pharmaceuticals Division, Macclesfield, UK) or insulin, or were given the two in combination [23].
  • In this study we examined the effects of a new nonselective endothelin receptor antagonist, TAK-044 (Takeda Chemical Industries, Ltd., Osaka, Japan), on burn trauma in rats [24].

Analytical, diagnostic and therapeutic context of Chemical Industry


  1. Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa). Mitomi, T., Tsuchiya, S., Iijima, N., Aso, K., Suzuki, K., Nishiyama, K., Amano, T., Takahashi, T., Murayama, N., Oka, H. Dis. Colon Rectum (1992) [Pubmed]
  2. Neurosurgical trauma in Japan. Maejima, S., Katayama, Y. World journal of surgery. (2001) [Pubmed]
  3. Thiomorpholine and morpholine oxidation by a cytochrome P450 in Mycobacterium aurum MO1. Evidence of the intermediates by in situ 1H NMR. Combourieu, B., Poupin, P., Besse, P., Sancelme, M., Veschambre, H., Truffaut, N., Delort, A.M. Biodegradation (1998) [Pubmed]
  4. The nature and transport mechanism of hydrated hydroxide ions in aqueous solution. Tuckerman, M.E., Marx, D., Parrinello, M. Nature (2002) [Pubmed]
  5. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Paech, K., Webb, P., Kuiper, G.G., Nilsson, S., Gustafsson, J., Kushner, P.J., Scanlan, T.S. Science (1997) [Pubmed]
  6. Formaldehyde in the British chemical industry. An occupational cohort study. Acheson, E.D., Barnes, H.R., Gardner, M.J., Osmond, C., Pannett, B., Taylor, C.P. Lancet (1984) [Pubmed]
  7. Slow component-a of axonal transport, nerve myo-inositol, and aldose reductase inhibition in streptozocin-diabetic rats. Tomlinson, D.R., Sidenius, P., Larsen, J.R. Diabetes (1986) [Pubmed]
  8. The Hairy and Enhancer of Split homologue-1 (HES-1) mediates the proliferative effect of 17beta-estradiol on breast cancer cell lines. Ström, A., Arai, N., Leers, J., Gustafsson, J.A. Oncogene (2000) [Pubmed]
  9. Clinical pharmacokinetics of unbound docetaxel: role of polysorbate 80 and serum proteins. Loos, W.J., Baker, S.D., Verweij, J., Boonstra, J.G., Sparreboom, A. Clin. Pharmacol. Ther. (2003) [Pubmed]
  10. Studies on the mechanism of 1,3-butadiene-induced leukemogenesis: the potential role of endogenous murine leukemia virus. Irons, R.D. Environ. Health Perspect. (1990) [Pubmed]
  11. Mercury: major issues in environmental health. Clarkson, T.W. Environ. Health Perspect. (1993) [Pubmed]
  12. Assessment of exposure to 2,4-dichlorophenoxyacetic acid in the chemical industry: results of a five year biological monitoring study. Knopp, D. Occupational and environmental medicine. (1994) [Pubmed]
  13. Bioavailability study of tablet Bezafibrate 200 mg (Lipocor). Ali, O., Khan, M.A., Obaid, R., Ahmed, S.W. Pakistan journal of pharmaceutical sciences. (2002) [Pubmed]
  14. Regulation of matrix metalloproteinase expression by estrogen in fibroblasts that are derived from the pelvic floor. Moalli, P.A., Klingensmith, W.L., Meyn, L.A., Zyczynski, H.M. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  15. Epidemiological studies of styrene-exposed populations. Coggon, D. Crit. Rev. Toxicol. (1994) [Pubmed]
  16. Dinitrotoluene: acute toxicity, oncogenicity, genotoxicity, and metabolism. Rickert, D.E., Butterworth, B.E., Popp, J.A. Crit. Rev. Toxicol. (1984) [Pubmed]
  17. Enzymatic asymmetric synthesis by decarboxylases. Ward, O.P., Singh, A. Curr. Opin. Biotechnol. (2000) [Pubmed]
  18. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. Timmermans, P.B., Carini, D.J., Chiu, A.T., Duncia, J.V., Price, W.A., Wells, G.J., Wong, P.C., Wexler, R.R., Johnson, A.L. Hypertension (1991) [Pubmed]
  19. Preadipocyte differentiation in vitro: identification of a highly active adipogenic agent. Hiragun, A., Sato, M., Mitsui, H. J. Cell. Physiol. (1988) [Pubmed]
  20. Hemodynamic and biochemical effects of endothelin-A- and -B-receptor antagonist TAK-044 in stroke-prone spontaneously hypertensive rats. Naruse, M., Tanabe, A., Naruse, K., Adachi, C., Yoshimoto, T., Seki, T., Takagi, S., Imaki, T., Watanabe, T., Takano, K. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  21. Ponalrestat: a potent and specific inhibitor of aldose reductase. Ward, W.H., Sennitt, C.M., Ross, H., Dingle, A., Timms, D., Mirrlees, D.J., Tuffin, D.P. Biochem. Pharmacol. (1990) [Pubmed]
  22. OECD test strategies and methods for endocrine disruptors. Gelbke, H.P., Kayser, M., Poole, A. Toxicology (2004) [Pubmed]
  23. Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil. Willars, G.B., Townsend, J., Tomlinson, D.R., Compton, A.M., Churchill, R.D. Metab. Clin. Exp. (1988) [Pubmed]
  24. Reduction of progressive burn injury by using a new nonselective endothelin-A and endothelin-B receptor antagonist, TAK-044: an experimental study in rats. Battal, M.N., Hata, Y., Matsuka, K., Ito, O., Matsuda, H., Yoshida, Y., Kawazoe, T. Plast. Reconstr. Surg. (1997) [Pubmed]
  25. A case-control study of hematopoietic and lymphoid neoplasms: the role of work in the chemical industry. Massoudi, B.L., Talbott, E.O., Day, R.D., Swerdlow, S.H., Marsh, G.M., Kuller, L.H. Am. J. Ind. Med. (1997) [Pubmed]
  26. Further examination of employment in the chemical industry: follow-up case-control study of hematopoietic and lymphoid neoplasms using a next consecutive death control group. Weimer, K., Talbott, E.O., Day, R.D. Am. J. Ind. Med. (1998) [Pubmed]
  27. A cohort study of mortality and cancer incidence in ethylene oxide production workers. Hogstedt, C., Rohlén, O., Berndtsson, B.S., Axelson, O., Ehrenberg, L. British journal of industrial medicine. (1979) [Pubmed]
  28. Spectrophotometric determination of dapsone in pharmaceutical products using sodium 1,2-naphthoquinone-4-sulfonic as the chromogenic reagent. Wang, H.Y., Xu, L.X., Xiao, Y., Han, J. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2004) [Pubmed]
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