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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Calmodulin activation of adenylate cyclase in pancreatic islets.

Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.[1]


  1. Calmodulin activation of adenylate cyclase in pancreatic islets. Valverde, I., Vandermeers, A., Anjaneyulu, R., Malaisse, W.J. Science (1979) [Pubmed]
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