Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

McLaren, J.W. et al.

Jay W. McLaren, Sanjay V. Patel, Sanjay V. Patel,

Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty.

PURPOSE: To evaluate the effects on visual acuity of forward scatter and aberrations typical of those after Descemet stripping endothelial keratoplasty (DSEK). METHODS: Twenty normal eyes of 20 subjects (ages 22-57 years) were examined with best spectacle correction. Under photopic conditions, high-contrast visual acuities (HCVAs) were measured by using ETDRS charts. Visual acuity was also measured by using aberrated charts that simulated the typical high-order aberrations at 12 months after DSEK. Forward scatter was induced by viewing the eye charts through a 1-mm-thick layer of scattering solution (Amco Clear, at a concentration of 4000 nephelometric turbidity units) and was measured with a straylight meter. RESULTS: Forward scatter increased from 1.19 ± 0.11 log straylight parameter (log[s]; mean ± SD) without induced scatter to 1.57 ± 0.06 log(s) with induced scatter (P < 0.001). Induced scatter reduced HCVA on the nonaberrated chart by 2.7 Snellen letters, from 20/19 (Snellen equivalent) to 20/21 (P < 0.001) and by 2.1 letters on the aberrated chart, from 20/25 to 20/28 (P = 0.005). Addition of aberrations reduced HCVA by more than twice the number of Snellen letters than did induced scatter, by 6.4 letters with low scatter (P < 0.001), and by 5.8 letters with high scatter (P < 0.001). CONCLUSIONS: Under typical clinical testing conditions, increased forward scatter has minimal effect on visual acuity. High-order aberrations are a more likely cause of degraded visual acuity than is forward scatter in eyes with clear corneas after DSEK.[1]

References

Modeling the effect of forward scatter and aberrations on visual acuity after endothelial keratoplasty. McLaren, J.W., Patel, S.V. Invest. Ophthalmol. Vis. Sci. (2012) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.