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MeSH Review

Corneal Transplantation

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Disease relevance of Corneal Transplantation


High impact information on Corneal Transplantation


Chemical compound and disease context of Corneal Transplantation


Biological context of Corneal Transplantation


Anatomical context of Corneal Transplantation

  • The presence of a layer of abnormal material in Descemet's membrane in eight keratoplasty specimens served as a marker to determine whether Chandler's syndrome, Essential Iris Atrophy, and the Cogan-Reese syndrome are congenital or acquired conditions [20].
  • It thus appears that the expression of MHC and leukocyte antigens by cells in the rat cornea is similar to that reported in the human, indicating that the rat may indeed provide a good model of human corneal transplantation [21].
  • Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies to keratin subgroups, vimentin, desmin, and a series of other antibodies against intermediate filaments [22].
  • Donor eyes, unsuitable for use in keratoplasty, were obtained from the Wisconsin Lions Eye Bank. The endothelium of each donor eye was examined using wide-field specular microscopy, and the specular micrographs were traced and digitized for the determination of cell density [23].
  • These results demonstrated that donor corneal endothelial cells preserved for up to one month at 34 C in 1.35% chondroitin sulfate appear to survive and function after keratoplasty as well as those preserved at 4 C for one to three days in McCarey-Kaufman medium [24].

Associations of Corneal Transplantation with chemical compounds


Gene context of Corneal Transplantation


Analytical, diagnostic and therapeutic context of Corneal Transplantation


  1. Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. Biswas, S., Munier, F.L., Yardley, J., Hart-Holden, N., Perveen, R., Cousin, P., Sutphin, J.E., Noble, B., Batterbury, M., Kielty, C., Hackett, A., Bonshek, R., Ridgway, A., McLeod, D., Sheffield, V.C., Stone, E.M., Schorderet, D.F., Black, G.C. Hum. Mol. Genet. (2001) [Pubmed]
  2. Hyperopia correction by noncontact holmium:YAG laser thermal keratoplasty. Clinical study with two-year follow-up. Koch, D.D., Abarca, A., Villarreal, R., Menefee, R., Kohnen, T., Vassiliadis, A., Berry, M. Ophthalmology (1996) [Pubmed]
  3. Epithelial abnormalities and sterile ulceration of epikeratoplasty grafts. Frangieh, G.T., Kenyon, K.R., Wagoner, M.D., Hanninen, L., John, T., Steinert, R.F. Ophthalmology (1988) [Pubmed]
  4. Tectonic corneal lamellar grafting for severe scleral melting after pterygium surgery. Ti, S.E., Tan, D.T. Ophthalmology (2003) [Pubmed]
  5. Biochemical and histological analysis of "recurrent' macular corneal dystrophy. Newsome, D.A., Hassell, J.R., Rodrigues, M.M., Rahe, A.E., Krachmer, J.H. Arch. Ophthalmol. (1982) [Pubmed]
  6. Reduced graft rejection with good HLA-A and B matching in high-risk corneal transplantation. Sanfilippo, F., MacQueen, J.M., Vaughn, W.K., Foulks, G.N. N. Engl. J. Med. (1986) [Pubmed]
  7. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. Stuart, P.M., Griffith, T.S., Usui, N., Pepose, J., Yu, X., Ferguson, T.A. J. Clin. Invest. (1997) [Pubmed]
  8. Penetration of mercury from ophthalmic preservatives into the human eye. Winder, A.F., Astbury, N.J., Sheraidah, G.A., Ruben, M. Lancet (1980) [Pubmed]
  9. Characterization of a novel cis-element that regulates Fas ligand expression in corneal endothelial cells. Zhang, J., Ma, B., Marshak-Rothstein, A., Fine, A. J. Biol. Chem. (1999) [Pubmed]
  10. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Beutelspacher, S.C., Pillai, R., Watson, M.P., Tan, P.H., Tsang, J., McClure, M.O., George, A.J., Larkin, D.F. Eur. J. Immunol. (2006) [Pubmed]
  11. Topical cyclosporin A in the management of therapeutic keratoplasty for mycotic keratitis. Perry, H.D., Doshi, S.J., Donnenfeld, E.D., Bai, G.S. Cornea (2002) [Pubmed]
  12. Application of mizoribine after keratoplasty and in the treatment of uveitis. Nakajima, A., Kanai, A., Minami, S., Kogure, M. Am. J. Ophthalmol. (1985) [Pubmed]
  13. Gentamicin-resistant streptococcal endophthalmitis after keratoplasty. Lindquist, T.D., Weber, K., Spika, J., Facklam, R. Cornea (1990) [Pubmed]
  14. Toxic endothelial degeneration in ocular surface disease treated with topical medications containing benzalkonium chloride. Lemp, M.A., Zimmerman, L.E. Am. J. Ophthalmol. (1988) [Pubmed]
  15. Role of natural killer cells in the rejection process of corneal allografts in rats. Claerhout, I., Kestelyn, P., Debacker, V., Beele, H., Leclercq, G. Transplantation (2004) [Pubmed]
  16. Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Cursiefen, C., Cao, J., Chen, L., Liu, Y., Maruyama, K., Jackson, D., Kruse, F.E., Wiegand, S.J., Dana, M.R., Streilein, J.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  17. Role of ABO and Lewis blood group antigens in donor-recipient compatibility of corneal transplantation rejection. Roy, R., Des Marchais, B., Bazin, R., Boisjoly, H.M., Dubé, I., Laughrea, P.A. Ophthalmology (1997) [Pubmed]
  18. Topical soluble tumor necrosis factor receptor type I suppresses ocular chemokine gene expression and rejection of allogeneic corneal transplants. Qian, Y., Dekaris, I., Yamagami, S., Dana, M.R. Arch. Ophthalmol. (2000) [Pubmed]
  19. Corneal graft survival in HLA-A- and HLA-B-matched transplantations in high-risk cases with retrospective review of HLA-DR compatibility. Beekhuis, W.H., van Rij, G., Renardel de Lavalette, J.G., Rinkel-van Driel, E., Persijn, G., D'Amaro, J. Cornea (1991) [Pubmed]
  20. Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. II. Estimated age at disease onset. Alvarado, J.A., Murphy, C.G., Juster, R.P., Hetherington, J. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  21. The expression of major histocompatibility complex and leukocyte antigens by cells in the rat cornea. Treseler, P.A., Sanfilippo, F. Transplantation (1986) [Pubmed]
  22. Immunohistochemical pathology of the corneal endothelium in iridocorneal endothelial syndrome. Hirst, L.W., Bancroft, J., Yamauchi, K., Green, W.R. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  23. Pump function of the human corneal endothelium. Effects of age and cornea guttata. Geroski, D.H., Matsuda, M., Yee, R.W., Edelhauser, H.F. Ophthalmology (1985) [Pubmed]
  24. Endothelial cell survival on transplanted human corneas preserved by organ culture with 1.35% chondroitin sulfate. Bourne, W.M., Lindstrom, R.L., Doughman, D.J. Am. J. Ophthalmol. (1985) [Pubmed]
  25. Immunosuppression with cyclosporine A and mycophenolate mofetil after penetrating high-risk keratoplasty: a retrospective study. Birnbaum, F., Böhringer, D., Sokolovska, Y., Sundmacher, R., Reinhard, T. Transplantation (2005) [Pubmed]
  26. Predicting refractive alterations with hydrogel keratophakia. Watsky, M.A., McCarey, B.E., Beekhuis, W.H. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  27. Coadministration of the new macrolide immunosuppressant RAD and mycophenolate mofetil in experimental corneal transplantation. Reis, A., Megahed, M., Reinhard, T., Godehardt, E., Spelsberg, H., Braunstein, C., Sundmacher, R. Transplantation (2000) [Pubmed]
  28. Macrophages play a role in the early phase of corneal allograft rejection in rats. Slegers, T.P., Broersma, L., van Rooijen, N., Hooymans, J.M., van Rij, G., van der Gaag, R. Transplantation (2004) [Pubmed]
  29. Inhibition of vascularization in rabbit corneas by heparin: cortisone pellets. Nikolic, L., Friend, J., Taylor, S., Thoft, R.A. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  30. Role of tumor necrosis factor receptors TNFR-I (P55) and TNFR-II (P75) in corneal transplantation. Yamada, J., Streilein, J.W., Dana, M.R. Transplantation (1999) [Pubmed]
  31. Association between HLA-DPB1 matching and 1-year rejection-free graft survival in high-risk corneal transplantation. Munkhbat, B., Hagihara, M., Sato, T., Tsuchida, F., Sato, K., Shimazaki, J., Tsubota, K., Tsuji, K. Transplantation (1997) [Pubmed]
  32. Mechanisms of immunotherapeutic intervention by anti-CD154 (CD40L) antibody in high-risk corneal transplantation. Qian, Y., Hamrah, P., Boisgerault, F., Yamagami, S., Vora, S., Benichou, G., Dana, M.R. J. Interferon Cytokine Res. (2002) [Pubmed]
  33. Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization. Cursiefen, C., Rummelt, C., Küchle, M. Cornea (2000) [Pubmed]
  34. Significant effect of high-resolution HLA-DRB1 matching in high-risk corneal transplantation. Baggesen, K., Lamm, L.U., Ehlers, N. Transplantation (1996) [Pubmed]
  35. Apoptosis induced by a corneal-endothelium-derived cytokine. Liu, S.H., Gottsch, J.D. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  36. Granular corneal dystrophy. Visual results and pattern of recurrence after lamellar or penetrating keratoplasty. Lyons, C.J., McCartney, A.C., Kirkness, C.M., Ficker, L.A., Steele, A.D., Rice, N.S. Ophthalmology (1994) [Pubmed]
  37. Laser thermal keratoplasty for the treatment of photorefractive keratectomy overcorrections: a 1-year follow-up. Pop, M. Ophthalmology (1998) [Pubmed]
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