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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Visual Acuity

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Disease relevance of Visual Acuity


Psychiatry related information on Visual Acuity


High impact information on Visual Acuity

  • Interestingly, eye pigment formation is reported to be normal in rp, but we found visual defects (nystagmus, iris transilluminancy, foveal hypoplasia, reduced visual acuity, and evidence of optic pathway misrouting) in affected individuals [11].
  • Patients with RP2 mutations had, on average, lower visual acuity but similar visual field area, final dark-adapted threshold, and 30-Hz ERG amplitude compared with those with RPGR mutations [12].
  • Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive disorder characterized clinically by grayish corneal deposits of amyloid and by severely impaired visual acuity [13].
  • Both patients exhibited pigment dilution, impaired visual acuity, nystagmus, a bleeding diathesis, and absent platelet dense bodies, confirming the diagnosis of HPS [14].
  • X-linked juvenile retinoschisis (RS) is a recessively inherited disorder resulting in poor visual acuity [15].

Chemical compound and disease context of Visual Acuity


Biological context of Visual Acuity


Anatomical context of Visual Acuity


Associations of Visual Acuity with chemical compounds


Gene context of Visual Acuity


Analytical, diagnostic and therapeutic context of Visual Acuity


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  2. Prednisone and cyclosporine in the treatment of severe Graves' ophthalmopathy. Prummel, M.F., Mourits, M.P., Berghout, A., Krenning, E.P., van der Gaag, R., Koornneef, L., Wiersinga, W.M. N. Engl. J. Med. (1989) [Pubmed]
  3. Deletion mapping of Aland Island eye disease to Xp21 between DXS67 (B24) and Duchenne muscular dystrophy. Pillers, D.A., Towbin, J.A., Chamberlain, J.S., Wu, D., Ranier, J., Powell, B.R., McCabe, E.R. Am. J. Hum. Genet. (1990) [Pubmed]
  4. Oa1 knock-out: new insights on the pathogenesis of ocular albinism type 1. Incerti, B., Cortese, K., Pizzigoni, A., Surace, E.M., Varani, S., Coppola, M., Jeffery, G., Seeliger, M., Jaissle, G., Bennett, D.C., Marigo, V., Schiaffino, M.V., Tacchetti, C., Ballabio, A. Hum. Mol. Genet. (2000) [Pubmed]
  5. A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C. Sunohara, N., Sakuragawa, N., Satoyoshi, E., Tanae, A., Shapiro, L.J. Ann. Neurol. (1986) [Pubmed]
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  13. Homozygosity mapping of a gene responsible for gelatinous drop-like corneal dystrophy to chromosome 1p. Tsujikawa, M., Kurahashi, H., Tanaka, T., Okada, M., Yamamoto, S., Maeda, N., Watanabe, H., Inoue, Y., Kiridoshi, A., Matsumoto, K., Ohashi, Y., Kinoshita, S., Shimomura, Y., Nakamura, Y., Tano, Y. Am. J. Hum. Genet. (1998) [Pubmed]
  14. Evidence for locus heterogeneity in Puerto Ricans with Hermansky-Pudlak syndrome. Hazelwood, S., Shotelersuk, V., Wildenberg, S.C., Chen, D., Iwata, F., Kaiser-Kupfer, M.I., White, J.G., King, R.A., Gahl, W.A. Am. J. Hum. Genet. (1997) [Pubmed]
  15. Linkage disequilibrium and physical mapping of X-linked juvenile retinoschisis. Huopaniemi, L., Rantala, A., Tahvanainen, E., de la Chapelle, A., Alitalo, T. Am. J. Hum. Genet. (1997) [Pubmed]
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  17. A randomized, controlled trial of oral high-dose methylprednisolone in acute optic neuritis. Sellebjerg, F., Nielsen, H.S., Frederiksen, J.L., Olesen, J. Neurology (1999) [Pubmed]
  18. Reduced visual function associated with infantile spasms in children on vigabatrin therapy. Hammoudi, D.S., Lee, S.S., Madison, A., Mirabella, G., Buncic, J.R., Logan, W.J., Snead, O.C., Westall, C.A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  19. A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. Whitcup, S.M., Csaky, K.G., Podgor, M.J., Chew, E.Y., Perry, C.H., Nussenblatt, R.B. Ophthalmology (1996) [Pubmed]
  20. Neurovisual impairment: a frequent complication of alpha-interferon treatment in chronic viral hepatitis. Manesis, E.K., Moschos, M., Brouzas, D., Kotsiras, J., Petrou, C., Theodosiadis, G., Hadziyannis, S. Hepatology (1998) [Pubmed]
  21. Viagra (sildenafil citrate) and ophthalmology. Laties, A., Zrenner, E. Progress in retinal and eye research. (2002) [Pubmed]
  22. Treatment of tuberculosis and tuberculosis infection in adults and children. American Thoracic Society and The Centers for Disease Control and Prevention. Bass, J.B., Farer, L.S., Hopewell, P.C., O'Brien, R., Jacobs, R.F., Ruben, F., Snider, D.E., Thornton, G. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  23. The benign concentric annular macular dystrophy locus maps to 6p12.3-q16. van Lith-Verhoeven, J.J., Hoyng, C.B., van den Helm, B., Deutman, A.F., Brink, H.M., Kemperman, M.H., de Jong, W.H., Kremer, H., Cremers, F.P. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  24. Efficacy of proton therapy in circumscribed choroidal hemangiomas associated with serious retinal detachment. Hannouche, D., Frau, E., Desjardins, L., Cassoux, N., Habrand, J.L., Offret, H. Ophthalmology (1997) [Pubmed]
  25. Oral zinc and the second eye in age-related macular degeneration. Stur, M., Tittl, M., Reitner, A., Meisinger, V. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  26. Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trial. Findl, O., Kriechbaum, K., Menapace, R., Koeppl, C., Sacu, S., Wirtitsch, M., Buehl, W., Drexler, W. Ophthalmology (2004) [Pubmed]
  27. Atypical presentation of pattern dystrophy in two families with peripherin/RDS mutations. Grover, S., Fishman, G.A., Stone, E.M. Ophthalmology (2002) [Pubmed]
  28. Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy. Ren, Z., Lin, P.Y., Klintworth, G.K., Iwata, F., Munier, F.L., Schorderet, D.F., El Matri, L., Theendakara, V., Basti, S., Reddy, M., Hejtmancik, J.F. Hum. Genet. (2002) [Pubmed]
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  30. Muscarinic antagonists in the treatment of acquired pendular and downbeat nystagmus: a double-blind, randomized trial of three intravenous drugs. Barton, J.J., Huaman, A.G., Sharpe, J.A. Ann. Neurol. (1994) [Pubmed]
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  33. Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Carlson, S.E., Werkman, S.H., Tolley, E.A. Am. J. Clin. Nutr. (1996) [Pubmed]
  34. Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. Pittasch, D., Lobmann, R., Behrens-Baumann, W., Lehnert, H. Diabetes Care (2002) [Pubmed]
  35. A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. Sanno, N., Teramoto, A., Osamura, R.Y., Genka, S., Katakami, H., Jin, L., Lloyd, R.V., Kovacs, K. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  36. Correlation of visual acuity and ocular pigmentation with the 16-bp duplication in the HPS-1 gene of Hermansky-Pudlak syndrome, a form of albinism. Iwata, F., Reed, G.F., Caruso, R.C., Kuehl, E.M., Gahl, W.A., Kaiser-Kupfer, M.I. Ophthalmology (2000) [Pubmed]
  37. Milder ocular findings in Hermansky-Pudlak syndrome type 3 compared with Hermansky-Pudlak syndrome type 1. Tsilou, E.T., Rubin, B.I., Reed, G.F., McCain, L., Huizing, M., White, J., Kaiser-Kupfer, M.I., Gahl, W. Ophthalmology (2004) [Pubmed]
  38. A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability. Patel, N., Sun, L., Moshinsky, D., Chen, H., Leahy, K.M., Le, P., Moss, K.G., Wang, X., Rice, A., Tam, D., Laird, A.D., Yu, X., Zhang, Q., Tang, C., McMahon, G., Howlett, A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  39. Three novel mutations of the RPGR gene exon ORF15 in three Japanese families with X-linked retinitis pigmentosa. Yokoyama, A., Maruiwa, F., Hayakawa, M., Kanai, A., Vervoort, R., Wright, A.F., Yamada, K., Niikawa, N., Naōi, N. Am. J. Med. Genet. (2001) [Pubmed]
  40. Grating, vernier, and letter acuity in retinitis pigmentosa. Alexander, K.R., Derlacki, D.J., Fishman, G.A., Szlyk, J.P. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  41. Topical retinoid treatment for various dry-eye disorders. Tseng, S.C., Maumenee, A.E., Stark, W.J., Maumenee, I.H., Jensen, A.D., Green, W.R., Kenyon, K.R. Ophthalmology (1985) [Pubmed]
  42. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Wilson, S.E. Ophthalmology (2001) [Pubmed]
  43. Grid laser photocoagulation for macular edema in bilateral juxtafoveal telangiectasis. Park, D.W., Schatz, H., McDonald, H.R., Johnson, R.N. Ophthalmology (1997) [Pubmed]
  44. Ocular manifestations of tuberculosis. Sheu, S.J., Shyu, J.S., Chen, L.M., Chen, Y.Y., Chirn, S.C., Wang, J.S. Ophthalmology (2001) [Pubmed]
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