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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Treatment of severe lichen planus with cyclosporine.

Two patients with severe chronic lichen planus were successfully treated with oral cyclosporine (6 mg/kg/day). A response was noted within 4 weeks, and complete clearing was achieved after 8 weeks of treatment. No significant adverse effect was noted. The patients have remained in remission 3 and 10 months after therapy, respectively. Clinical improvement was accompanied by significant reduction in the T cell infiltrate in the skin. Abnormal expression of keratinocyte intercellular adhesion molecule-1 (ICAM-1), which was present before therapy, became undetectable after 1 week of cyclosporine therapy, before any significant clinical and histologic change.[1]

References

  1. Treatment of severe lichen planus with cyclosporine. Ho, V.C., Gupta, A.K., Ellis, C.N., Nickoloff, B.J., Voorhees, J.J. J. Am. Acad. Dermatol. (1990) [Pubmed]
 
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