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MeSH Review

Lichen Planus

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Disease relevance of Lichen Planus


High impact information on Lichen Planus


Chemical compound and disease context of Lichen Planus


Biological context of Lichen Planus


Anatomical context of Lichen Planus


Gene context of Lichen Planus

  • MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions [24].
  • Phenylethanolamine N-methyltransferase (PNMT)-like immunoreactivity has been found in psoriatic skin and in this study, PNMT-like immunoreactivity was investigated in the involved and uninvolved skin of six patients with lichen planus and four patients with lichen simplex [25].
  • In our case report predisposition to cutaneous idiopathic lichen planus is correlated with a valine in position 85 and a glycine in position 86 at the second exon of the DRB1 gene [18].
  • The number of keratinocytes in per mm2 of epidermis stained for RANTES were 116.79+/-98.42 in psoriatic tissues compared to 32.00+/-46.05 (p<0.05), 6.39+/-3.59 (p<0.01), 2.64 +/-1.15 (p<0.01) and 3.53+/-5.26 (p<0.01), respectively, in the non-lesional, lichen planus, eczematous lesions and normal skin [26].
  • In the present study, an analysis was made of the expression pattern of thrombospondin-1 (TSP1) and its receptor (CD36) in skin biopsies obtained from healthy volunteers and from patients with lichen planus, lupus erythematosus, cutaneous T-cell lymphoma and psoriasis vulgaris [27].

Analytical, diagnostic and therapeutic context of Lichen Planus


  1. Primary biliary cirrhosis, penicillamine, and lichen planus. Powell, F.C., Rogers, R.S. Lancet (1981) [Pubmed]
  2. Extrahepatic manifestations of hepatitis C among United States male veterans. El-Serag, H.B., Hampel, H., Yeh, C., Rabeneck, L. Hepatology (2002) [Pubmed]
  3. Differential staining of cytoid bodies and skin-limited amyloids with monoclonal anti-keratin antibodies. Eto, H., Hashimoto, K., Kobayashi, H., Fukaya, T., Matsumoto, M., Sun, T.T. Am. J. Pathol. (1984) [Pubmed]
  4. C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. Fayyazi, A., Sandau, R., Duong, L.Q., Götze, O., Radzun, H.J., Schweyer, S., Soruri, A., Zwirner, J. Am. J. Pathol. (1999) [Pubmed]
  5. Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. Flier, J., Boorsma, D.M., van Beek, P.J., Nieboer, C., Stoof, T.J., Willemze, R., Tensen, C.P. J. Pathol. (2001) [Pubmed]
  6. Treatment of lichen planus with temarotene. Bollag, W., Ott, F. Lancet (1989) [Pubmed]
  7. Killer cell immunoglobulin-like receptor expression delineates in situ Sézary syndrome lymphocytes. Wechsler, J., Bagot, M., Nikolova, M., Parolini, S., Martin-Garcia, N., Boumsell, L., Moretta, A., Bensussan, A. J. Pathol. (2003) [Pubmed]
  8. Telomerase components as a diagnostic tool in human oral lesions. Sumida, T., Hamakawa, H., Sogawa, K., Sugita, A., Tanioka, H., Ueda, N. Int. J. Cancer (1999) [Pubmed]
  9. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. Zillikens, D., Caux, F., Mascaro, J.M., Wesselmann, U., Schmidt, E., Prost, C., Callen, J.P., Bröcker, E.B., Diaz, L.A., Giudice, G.J. J. Invest. Dermatol. (1999) [Pubmed]
  10. Destruction of the epithelial anchoring system in lichen planus. Haapalainen, T., Oksala, O., Kallioinen, M., Oikarinen, A., Larjava, H., Salo, T. J. Invest. Dermatol. (1995) [Pubmed]
  11. Globular deposits of immunoglobulins and complement in the papillary dermis. Clinical significance. Gogate, P., Valenzuela, R., Deodhar, S.D., Bergfeld, W.F., Yeip, M. Am. J. Clin. Pathol. (1980) [Pubmed]
  12. Does hydroxyethyl starch cause lichen planus? Lichen planus in a long-time routine blood donor never exposed to hydroxyethyl starch. Newman, R.S., Barr, R.J., Ocariz, J.A., Kaplan, H.S. Transfusion (1983) [Pubmed]
  13. Treatment of severe lichen planus with cyclosporine. Ho, V.C., Gupta, A.K., Ellis, C.N., Nickoloff, B.J., Voorhees, J.J. J. Am. Acad. Dermatol. (1990) [Pubmed]
  14. Use of monoclonal antibodies specific for T cell subsets in cutaneous disorders: II. Immunomorphological studies in blood and skin lesions. Schmitt, D., Thivolet, J. J. Clin. Immunol. (1982) [Pubmed]
  15. Keratin expression in cutaneous lichen planus. Schofield, J.K., De Berker, D., Milligan, A., Rohloff, W., Marren, P., Davies, M.G., Burge, S., Graham-Brown, R., Leigh, I.M. Histopathology (1995) [Pubmed]
  16. Comparative analysis of HLA polymorphism at the serologic and molecular level in Moroccan and Ashkenazi Jews. Roitberg-Tambur, A., Witt, C.S., Friedmann, A., Safirman, C., Sherman, L., Battat, S., Nelken, D., Brautbar, C. Tissue Antigens (1995) [Pubmed]
  17. Ultrastructural localization of the binding sites of antibasement membrane zone antibodies in lichen planus pemphigoides on 1.0 M sodium chloride-separated skin. Ikeda, S., Song, Y., Yaguchi, H., Naito, K., Morioka, S., Ogawa, H., Muramatsu, T. Arch. Dermatol. Res. (1989) [Pubmed]
  18. The HLA-DRB1*0101 allele is responsible for HLA susceptibility to lichen ruber planus. Carcassi, C., Cottoni, F., Floris, L., La Nasa, G., Mulargia, M., Baldini, G., Senes, G., Orru, S., Montesu, M.A., Cerimele, D. Eur. J. Immunogenet. (1994) [Pubmed]
  19. In three types of interface dermatitis, different patterns of expression of intercellular adhesion molecule-1 (ICAM-1) indicate different triggers of disease. Bennion, S.D., Middleton, M.H., David-Bajar, K.M., Brice, S., Norris, D.A. J. Invest. Dermatol. (1995) [Pubmed]
  20. T-cell lines derived from lesional skin of lichen planus patients contain a distinctive population of T-cell receptor gamma delta-bearing cells. Gadenne, A.S., Strucke, R., Dunn, D., Wagner, M., Bleicher, P., Bigby, M. J. Invest. Dermatol. (1994) [Pubmed]
  21. Altered expression of basement membrane proteins and their integrin receptors in lichen planus: possible pathogenetic role of gelatinases A and B. Giannelli, G., Brassard, J., Foti, C., Stetler-Stevenson, W.G., Falk-Marzillier, J., Zambonin-Zallone, A., Schiraldi, O., Quaranta, V. Lab. Invest. (1996) [Pubmed]
  22. Donor toxicity in granulocyte collections: association of lichen planus with the use of hydroxyethyl starch leukapheresis. Bode, U., Deisseroth, A.B. Transfusion (1981) [Pubmed]
  23. Immunohistologic evaluation of the effect of cyclosporine treatment on the lichen planus immune infiltrate. Mozzanica, N., Cattaneo, A., Legori, A., Pigatto, P., Finzi, A.F. J. Am. Acad. Dermatol. (1991) [Pubmed]
  24. MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions. Spandau, U., Toksoy, A., Goebeler, M., Bröcker, E.B., Gillitzer, R. J. Invest. Dermatol. (1998) [Pubmed]
  25. The specificity and cellular origin of phenylethanolamine N-methyltransferase (PNMT)-like immunoreactivity in psoriatic skin. Johansson, O., Olsson, A., Enhamre, A., Fransson, J., Hammar, H., Han, S.W., Goldstein, M. Br. J. Dermatol. (1990) [Pubmed]
  26. Upregulation of RANTES in psoriatic keratinocytes: a possible pathogenic mechanism for psoriasis. Raychaudhuri, S.P., Jiang, W.Y., Farber, E.M., Schall, T.J., Ruff, M.R., Pert, C.B. Acta Derm. Venereol. (1999) [Pubmed]
  27. Expression of thrombospondin-1 (TSP1) and its receptor (CD36) in healthy and diseased human skin. Bégány, A., Simon, M., Dehmel, N., Hunyadi, J. Acta Derm. Venereol. (1994) [Pubmed]
  28. Preservation of specific fluorescence by sealing with nail polish. Soltani, K., Taylor, M.E., Choy, R.K. J. Invest. Dermatol. (1976) [Pubmed]
  29. Endothelial chemokines in autoimmune disease. Christopherson, K.W., Hromas, R.A. Curr. Pharm. Des. (2004) [Pubmed]
  30. Antinuclear antibodies in patients with lichen planus. Carrizosa, A.M., Elorza, F.L., Camacho, F.M. Exp. Dermatol. (1997) [Pubmed]
  31. The reliability of immunofluorescence and histopathology in the diagnosis of discoid lupus erythematosus and lichen planus. Nieboer, C. Br. J. Dermatol. (1987) [Pubmed]
  32. Carbohydrate metabolism in lichen planus. Lowe, N.J., Cudworth, A.G., Clough, S.A., Bullen, M.F. Br. J. Dermatol. (1976) [Pubmed]
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