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Fuchs, S.A. et al.

Sabine A. Fuchs, Martin W. Roeleveld, Leo W. J. Klomp, Ruud Berger, Tom J. de Koning, Martin W. Roeleveld, Leo W. J. Klomp, Ruud Berger, Tom J. de Koning,

D-serine influences synaptogenesis in a p19 cell model.

Recently, D-serine has been identified as an important NMDA-receptor co-agonist, which might play a role in central nervous system development. We investigated this by studying rat P19 cells, an established model for neuronal and glial differentiation. Our results show that (1) the D-serine synthesizing enzyme serine racemase was expressed upon differentiation, (2) extracellular D-serine concentrations increased upon differentiation, which was inhibited by serine racemase antagonism, and (3) inhibition of D-serine synthesis or prevention of D-serine binding to the NMDA-receptor increased synaptophysin expression and intercellular connections, supporting a role for NMDA-receptor activation by D-serine, synthesized by serine racemase, in shaping synaptogenesis and neuronal circuitry during central nervous system development. In conjunction with recent evidence from literature, we therefore suggest that D-serine deficiency might be responsible for the severe neurological phenotype seen in patients with serine deficiency disorders. In addition, this may provide a pathophysiological mechanism for a role of D-serine deficiency in psychiatric disorders.[1]

References

D-serine influences synaptogenesis in a p19 cell model. Fuchs, S.A., Roeleveld, M.W., Klomp, L.W., Berger, R., de Koning, T.J. JIMD. Rep (2012) [Pubmed]

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