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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Inhibition of human T-cell lymphotropic virus type III in vitro by phosphonoformate.

Phosphonoformate, an inhibitor of reverse transcriptase in a number of retroviruses, was shown to have a dose-related inhibitory effect on human T-cell lymphotropic virus type III (HTLV-III) replication in the H9 cell line in vitro. HTLV-III replication was eliminated at a concentration of 680 mumol, a non-cytotoxic dose. A lower dose of 132 mumol inhibited HTLV-III replication by more than 98%, as measured by reverse transcriptase activity, compared with untreated infected cultures. Reverse transcriptase activity in HTLV-III particles was completely inhibited by 5.0 mumol phosphonoformate.[1]


  1. Inhibition of human T-cell lymphotropic virus type III in vitro by phosphonoformate. Sandstrom, E.G., Kaplan, J.C., Byington, R.E., Hirsch, M.S. Lancet (1985) [Pubmed]
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