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Chemical Compound Review

Foscavir     phosphonomethanoic acid

Synonyms: Triapten, Foscarmet, Virudin, foscarnet, CHEMBL666, ...
 
 
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Disease relevance of phosphonoformic acid

 

Psychiatry related information on phosphonoformic acid

  • Increased liver enzymes, hallucinations and tremor were seen in one uraemic patient and coincided with foscarnet plasma concentrations above 400 mg/l. Among 25 patients evaluated for clinical efficacy, 12 died [6].
  • CASE REPORT: A 2-years-old male infant was referred to our department with a history of Epstein-Barr virus (EBV) encephalitis, treated with foscarnet and steroids, for he developed mutism and ataxia and loss of the ability to eat, walk and talk [7].
 

High impact information on phosphonoformic acid

 

Chemical compound and disease context of phosphonoformic acid

 

Biological context of phosphonoformic acid

 

Anatomical context of phosphonoformic acid

 

Associations of phosphonoformic acid with other chemical compounds

 

Gene context of phosphonoformic acid

 

Analytical, diagnostic and therapeutic context of phosphonoformic acid

References

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  2. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. Safrin, S., Crumpacker, C., Chatis, P., Davis, R., Hafner, R., Rush, J., Kessler, H.A., Landry, B., Mills, J. N. Engl. J. Med. (1991) [Pubmed]
  3. Foscarnet for CMV retinitis. Wood, C.A. Lancet (1992) [Pubmed]
  4. Inhibition of human T-cell lymphotropic virus type III in vitro by phosphonoformate. Sandstrom, E.G., Kaplan, J.C., Byington, R.E., Hirsch, M.S. Lancet (1985) [Pubmed]
  5. Foscarnet in fulminant hepatitis B. Price, J.S., France, A.J., Moaven, L.D., Welsby, P.D. Lancet (1986) [Pubmed]
  6. Pharmacokinetics, safety and preliminary clinical experiences using foscarnet in the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients. Ringdén, O., Lönnqvist, B., Paulin, T., Ahlmén, J., Klintmalm, G., Wahren, B., Lernestedt, J.O. J. Antimicrob. Chemother. (1986) [Pubmed]
  7. Transcranial magnetic stimulation. A case report and review of the literature. Anninos, P., Kotini, A., Tamiolakis, D., Tsagas, N. Acta neurologica Belgica. (2006) [Pubmed]
  8. Trisodium phosphonoformate, a new antiviral compound. Helgstrand, E., Eriksson, B., Johansson, N.G., Lannerö, B., Larsson, A., Misiorny, A., Norén, J.O., Sjöberg, B., Stenberg, K., Stening, G., Stridh, S., Oberg, B. Science (1978) [Pubmed]
  9. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. Mesri, E.A., Cesarman, E., Arvanitakis, L., Rafii, S., Moore, M.A., Posnett, D.N., Knowles, D.M., Asch, A.S. J. Exp. Med. (1996) [Pubmed]
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  14. Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase. Arion, D., Sluis-Cremer, N., Parniak, M.A. J. Biol. Chem. (2000) [Pubmed]
  15. Role of the progressive ankylosis gene (ank) in cartilage mineralization. Wang, W., Xu, J., Du, B., Kirsch, T. Mol. Cell. Biol. (2005) [Pubmed]
  16. The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production. Klass, C.M., Krug, L.T., Pozharskaya, V.P., Offermann, M.K. Blood (2005) [Pubmed]
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  18. Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance. Canestri, A., Ghosn, J., Wirden, M., Marguet, F., Ktorza, N., Boubezari, I., Dominguez, S., Bossi, P., Caumes, E., Calvez, V., Katlama, C. Antivir. Ther. (Lond.) (2006) [Pubmed]
  19. Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. Foster, S.A., Cerny, J., Cheng, Y.C. J. Biol. Chem. (1991) [Pubmed]
  20. In vitro effect of foscarnet on expansion of T-cells from people with LAS and AIDS. Beldekas, J.C., Levy, E.M., Black, P., Von Krogh, G., Sandstrom, E. Lancet (1985) [Pubmed]
  21. Uvula and oesophageal ulcerations with foscarnet. Saint-Marc, T., Fournier, F., Touraine, J.L., Marneff, E. Lancet (1992) [Pubmed]
  22. Randomized multicenter trial of foscarnet versus ganciclovir for preemptive therapy of cytomegalovirus infection after allogeneic stem cell transplantation. Reusser, P., Einsele, H., Lee, J., Volin, L., Rovira, M., Engelhard, D., Finke, J., Cordonnier, C., Link, H., Ljungman, P. Blood (2002) [Pubmed]
  23. Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. Eckle, T., Prix, L., Jahn, G., Klingebiel, T., Handgretinger, R., Selle, B., Hamprecht, K. Blood (2000) [Pubmed]
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  25. Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors. Sardana, V.V., Emini, E.A., Gotlib, L., Graham, D.J., Lineberger, D.W., Long, W.J., Schlabach, A.J., Wolfgang, J.A., Condra, J.H. J. Biol. Chem. (1992) [Pubmed]
  26. Phosphonocarboxylic acids as specific inhibitors of Na+-dependent transport of phosphate across renal brush border membrane. Szczepanska-Konkel, M., Yusufi, A.N., VanScoy, M., Webster, S.K., Dousa, T.P. J. Biol. Chem. (1986) [Pubmed]
  27. Effects of acyclovir combined with other antiviral agents on human cytomegalovirus. Spector, S.A., Tyndall, M., Kelley, E. Am. J. Med. (1982) [Pubmed]
  28. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Cecil, D.L., Rose, D.M., Terkeltaub, R., Liu-Bryan, R. Arthritis Rheum. (2005) [Pubmed]
  29. Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy. Chou, S., Marousek, G., Parenti, D.M., Gordon, S.M., LaVoy, A.G., Ross, J.G., Miner, R.C., Drew, W.L. J. Infect. Dis. (1998) [Pubmed]
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  32. Inflammatory cells in transplanted kidneys are infected by human cytomegalovirus. Gnann, J.W., Ahlmén, J., Svalander, C., Olding, L., Oldstone, M.B., Nelson, J.A. Am. J. Pathol. (1988) [Pubmed]
  33. A dose escalation study to determine the toxicity and maximally tolerated dose of foscarnet. Seidel, E.A., Koenig, S., Polis, M.A. AIDS (1993) [Pubmed]
  34. Rapid progression of HIV disease in children with cytomegalovirus DNAemia. Nigro, G., Krzysztofiak, A., Gattinara, G.C., Mango, T., Mazzocco, M., Porcaro, M.A., Provvedi, S., Booth, J.C. AIDS (1996) [Pubmed]
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