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Neurotrophic effects of beta endorphin C-terminal tetrapeptide ( MPF).

The ability of newts and other urolele amphibians to regenerate an accidentally-removed or amputated limb is lost after hypophysectomy, but restored following intraperitoneal injection of beta endorphin, or the C-terminal tetrapeptide sequence of human beta endorphin, Lys-Lys-Gly-Glu (= MPF). The closely related tetrapeptide, Lys-Lys-Gly-Gln (the C-terminal sequence of pig, sheep, and camel beta endorphin), the dipeptide Gly-Glu, the enkephalins, and other N-terminal sequences of beta endorphin (eg gamma endorphin) do not elicit the effect.[1]

References

  1. Neurotrophic effects of beta endorphin C-terminal tetrapeptide (MPF). Morley, J.S., Ensor, D.M. Neuropeptides (1986) [Pubmed]
 
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