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MeSH Review


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Disease relevance of Hypophysectomy


Psychiatry related information on Hypophysectomy


High impact information on Hypophysectomy


Chemical compound and disease context of Hypophysectomy


Biological context of Hypophysectomy


Anatomical context of Hypophysectomy


Associations of Hypophysectomy with chemical compounds


Gene context of Hypophysectomy

  • Vasoactive intestinal polypeptide (VIP)- and peptide histidine-isoleucine (PHI)-IR fibers in hypophysectomized animals had already contacted portal vessels 5 d after hypophysectomy, and from then on progressively increased in numbers [31].
  • Hypophysectomy (HPX) produced a 3-5-fold decrease in Star mRNA along with a loss of adrenal steroids, whereas P450scc mRNA decreased by less than 2-fold [32].
  • The three serine protease inhibitor (SPI) rat genes expressed preferentially in liver share considerable structural features and, nonetheless, are transcriptionally regulated in completely different manners, more particularly after hypophysectomy or upon acute inflammation [33].
  • Second, hypophysectomy disrupted basal activation of Stat5, an effect that was completely reversed by administration of PRL, but only partially by GH [34].
  • We reported earlier that in adult rats, HNF-6 mRNA concentration in liver drops to almost undetectable levels after hypophysectomy and returns to normal after 1 week of GH treatment [35].

Analytical, diagnostic and therapeutic context of Hypophysectomy


  1. Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy. Pollak, M., Sem, A.W., Richard, M., Tetenes, E., Bell, R. J. Natl. Cancer Inst. (1992) [Pubmed]
  2. Extrasellar, intracavernous sinus adrenocorticotropin-releasing adenoma causing Cushing's disease. Wilson, C.B., Mindermann, T., Tyrrell, J.B. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  3. Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances. Matsukura, S., Kakita, T., Hirata, Y., Yoshimi, H., Fukase, M. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  4. Central effects of CRF on metabolism and energy balance. Rothwell, N.J. Neuroscience and biobehavioral reviews. (1990) [Pubmed]
  5. Changes of endocrine properties of a transplantable, multihormonal, pituitary tumor (MtT-F4) after hypophysectomy of host rats. Lis, M., Guerinot, C., Chrétien, M. Endocrinology (1975) [Pubmed]
  6. Hypophysectomy in monosodium glutamate-pretreated rats suppresses paradoxical sleep rebound. Zhang, J.X., Valatx, J.L., Jouvet, M. Neurosci. Lett. (1988) [Pubmed]
  7. Noradrenergic feeding elicited via the paraventricular nucleus is dependent upon circulating corticosterone. Leibowitz, S.F., Roland, C.R., Hor, L., Squillari, V. Physiol. Behav. (1984) [Pubmed]
  8. The role of growth hormone in alpha 2u globulin synthesis: a reexamination. Lynch, K.R., Dolan, K.P., Nakhasi, H.L., Unterman, R., Feigelson, P. Cell (1982) [Pubmed]
  9. Sertoli cell secretory function after hypophysectomy. Weddington, S.C., Hansson, V., Ritzen, E.M., Hagenas, L., French, F.S., Nayfeh, S.N. Nature (1975) [Pubmed]
  10. Control of alternative splicing of potassium channels by stress hormones. Xie, J., McCobb, D.P. Science (1998) [Pubmed]
  11. Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Taché, Y., Goto, Y., Gunion, M.W., Vale, W., River, J., Brown, M. Science (1983) [Pubmed]
  12. Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex. Viveros, O.H., Lee, C.L., Abou-Donia, M.M., Nixon, J.C., Nichol, C.A. Science (1981) [Pubmed]
  13. Isolation of human-mouse somatic cell hybrids producing human prolactin: dominant expression of hormone secretion and regulation. Melmed, S. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  14. Hormonal regulation of epidermal tumor development. Lupulescu, A. J. Invest. Dermatol. (1981) [Pubmed]
  15. Effects of hypophysectomy on alloxan-diabetic, arteriosclerotic, breeder vs. non-arteriosclerotic, virgin rats. Wexler, B.C. Atherosclerosis (1976) [Pubmed]
  16. Effects of androgen injections and decapitation on the pituitary-gonadal axis and genital tract of fetal rats at the end of gestation. Naessany, S., Habert, R., Picon, R. J. Endocrinol. (1981) [Pubmed]
  17. Variable stabilities and recoveries of rat-liver RNA polymerases A and B according to growth status of the tissue. Shields, D., Tata, J.R. Eur. J. Biochem. (1976) [Pubmed]
  18. Somatomedin C: restoration in vivo of cycle traverse in G0/G1 blocked cells of hypophysectomized animals. Rothstein, H., Van Wyk, J.J., Hayden, J.H., Gordon, S.R., Weinsieder, A. Science (1980) [Pubmed]
  19. Primate mammary development. Effects of hypophysectomy, prolactin inhibition, and growth hormone administration. Kleinberg, D.L., Niemann, W., Flamm, E., Cooper, P., Babitsky, G., Valensi, Q. J. Clin. Invest. (1985) [Pubmed]
  20. Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. Hunziker, E.B., Wagner, J., Zapf, J. J. Clin. Invest. (1994) [Pubmed]
  21. Cell-specific expression of kidney androgen-regulated protein messenger RNA is under multihormonal control. Meseguer, A., Catterall, J.F. Mol. Endocrinol. (1990) [Pubmed]
  22. Effect of cis-platinum on heme, drug, and steroid metabolism pathways: possible involvement in nephrotoxicity and infertility. Maines, M.D. Crit. Rev. Toxicol. (1990) [Pubmed]
  23. Prolactin-like immunoreactivity: localization in nerve terminals of rat hypothalamus. Fuxe, K., Hökfelt, T., Eneroth, P., Gustafsson, J.A., Skett, P. Science (1977) [Pubmed]
  24. Control and localization of rat adrenal cyclic guanosine 3', 5'-monophosphate. Comparison with adrenal cyclic adenosine 3', 5'-monophosphate. Whitley, T.H., Stowe, N.W., Ong, S.H., ey, R.L., Steiner, A.L. J. Clin. Invest. (1975) [Pubmed]
  25. Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells. Lai, G.J., McCobb, D.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  26. Effects of hypophysectomy and dexamethasone administration on central and peripheral S-adenosylmethionine levels. Wong, D.L., Zager, E.L., Ciaranello, R.D. J. Neurosci. (1982) [Pubmed]
  27. Dissociation of heme metabolic activities from the microsomal cytochrome P-450 turnover in testis of hypophysectomized rats. Maines, M.D., Jollie, D.R. J. Biol. Chem. (1984) [Pubmed]
  28. Prolactin receptors in rat liver: possible induction by prolactin. Posner, B.I., Kelly, P.A., Friesen, H.G. Science (1975) [Pubmed]
  29. Insulin-dependent diabetes mellitus. Sudden onset following hypophysectomy in an acromegalic patient. Bunick, E.M., Schmidek, H., Lavine, R.L., Garofano, C.D., Rose, L.I. JAMA (1977) [Pubmed]
  30. Hydrazine sulfate protects D-galactosamine-sensitized mice against endotoxin and tumor necrosis factor/cachectin lethality: evidence of a role for the pituitary. Silverstein, R., Turley, B.R., Christoffersen, C.A., Johnson, D.C., Morrison, D.C. J. Exp. Med. (1991) [Pubmed]
  31. Reorganization of neural peptidergic systems in the median eminence after hypophysectomy. Villar, M.J., Meister, B., Hökfelt, T. J. Neurosci. (1994) [Pubmed]
  32. Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA. ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein. Ariyoshi, N., Kim, Y.C., Artemenko, I., Bhattacharyya, K.K., Jefcoate, C.R. J. Biol. Chem. (1998) [Pubmed]
  33. Analysis of proteins binding to the proximal promoter region of two rat serine protease inhibitor genes. Rossi, V., Rouayrenc, J.F., Paquereau, L., Vilarem, M.J., Le Cam, A. Nucleic Acids Res. (1992) [Pubmed]
  34. Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium. Nevalainen, M.T., Xie, J., Bubendorf, L., Wagner, K.U., Rui, H. Mol. Endocrinol. (2002) [Pubmed]
  35. Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone. Lahuna, O., Rastegar, M., Maiter, D., Thissen, J.P., Lemaigre, F.P., Rousseau, G.G. Mol. Endocrinol. (2000) [Pubmed]
  36. Regulation of O6-methylguanine-DNA methyltransferase levels in rat liver and kidney. Pegg, A.E., Wiest, L. Cancer Res. (1983) [Pubmed]
  37. Failure of hypophysectomy to correct pituitary-dependent Cushing's disease in two patients. Cook, D.M., McCarthy, P.J. Arch. Intern. Med. (1988) [Pubmed]
  38. Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity. Lemoine, A., Williams, D.E., Cresteil, T., Leroux, J.P. Mol. Pharmacol. (1991) [Pubmed]
  39. Effect of hypophysectomy on immunocytochemically demonstrated gonadotropin-releasing hormone in the rat brain. Baker, B.L., Dermody, W.C. Endocrinology (1976) [Pubmed]
  40. Luteinizing hormone requirements for ovulation in the pentobarbital-treated proestrous rat. Gosden, R.G., Everett, J.W., Tyrey, L. Endocrinology (1976) [Pubmed]
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