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Disease relevance of Salamandridae


Psychiatry related information on Salamandridae


High impact information on Salamandridae

  • In vitro analysis further revealed that 7alpha-hydroxypregnenolone treatment resulted in a dose-dependent increase in the release of dopamine from cultured brain tissue of nonbreeding newts [3].
  • In this paper, we describe expression of FGF-1 and its receptors, FGFR-2 (KGFR and bek variants) and FGFR-3, in newts during lens regeneration [4].
  • In the present study, nickel subsulfide (Ni3S2) was administered to lentectomized Japanese common newts, Cynops pyrrhogaster, by a single injection into the posterior chamber of the right eye (40-100 micrograms Ni3S2/newt) [5].
  • We show here that, in two urodele amphibians, newts and axolotls, the regulation of Tbx4 and Tbx5 differs from higher vertebrates [6].
  • Pigment cell pattern formation in Taricha torosa: the role of the extracellular matrix in controlling pigment cell migration and differentiation [7].

Biological context of Salamandridae


Anatomical context of Salamandridae

  • Inasmuch as the pattern of Hox C6 expression is similar in developing forelimb buds of larvae and epimorphically regenerating forelimb blastemata of both adults and larvae, our results support the paradigm that epimorphic regeneration in adult newts parallels larval forelimb development [13].
  • Rapid corticosterone-induced impairment of amplectic clasping occurs in the spinal cord of roughskin newts (taricha granulosa) [10].
  • Because arginine vasotocin (AVT) activates male sexual behaviors in the rough-skinned newt (Taricha granulosa), quantitative autoradiography with radiolabelled arginine vasopressin (3H-AVP) was used to characterize putative AVT receptors in the telencephalon of this amphibian [14].
  • Eel electroplax mRNA was injected into oocytes of newts (Cynops pyrrhogaster) and the injection induced synthesis of a nicotinic acetylcholine receptor in the oocyte membrane [15].
  • Further experiments on this mixture with Italian Great Newts and on the carbon tetrafluoride mixtures CF4-Ar and CF4-SF6 with mice suggested that the anomalous potencies may arise from specific pulmonary effects associated with the breathing of SF6 accompanied by a high pressure of some other gas [16].

Associations of Salamandridae with chemical compounds

  • Immunohistochemistry was used to investigate the neuroanatomical distribution of androgen and estrogen receptors in brains of adult male roughskin newts, Taricha granulosa, collected during the breeding season [17].
  • The present study utilized immunocytochemical techniques to determine whether the posterior GnRH group is present in a urodele amphibian, the newt Taricha granulosa [18].
  • Immunohistochemical and in situ hybridization techniques were used to investigate the neuroanatomical distribution of arginine vasotocin-like systems in the roughskin newt (Taricha granulosa) [19].
  • In the abdominal gland of newts treated with prolactin (PRL) plus testosterone propionate (TP), silefrin precursor mRNA expression was markedly enhanced as compared with that in the newts injected with saline, PRL, or TP [20].
  • In the roughskin newt (Taricha granulosa), exogenous corticosterone (CORT) rapidly blocks and vasotocin (VT) enhances reproductive behaviors (mainly clasping behavior) [21].

Gene context of Salamandridae

  • Expression of FGF2 in the limb blastema of two Salamandridae correlates with their regenerative capability [22].
  • As a step to elucidate the localization of neurons on which PRL acts, we developed a polyclonal antibody against an oligopeptide having a sequence completely identical with a part of the sequence of PRL receptors (PRLRs) of two species of newts, C. pyrrhogaster and C. ensicauda, and performed an immunohistochemical study with this antibody [23].
  • RT-PCR coupled with Southern blot analysis showed that the PRLR gene was transcribed broadly in newt organs and revealed that PRLR mRNA levels in the abdominal gland were much higher in sexually developed newts than in the sexually undeveloped ones [24].
  • Taricha granulosa, the roughskin newt, was used here to characterize an amphibian cannabinoid receptor [25].
  • HX produced a substantial fall in serum [Na+] in BC newts, while either PRL or ACTH replacement elevated serum [Na+] [26].

Analytical, diagnostic and therapeutic context of Salamandridae


  1. J10 lactate-induced polycythemia in newts. Frangioni, G., Borgioli, G. J. Exp. Zool. (1983) [Pubmed]
  2. Corticotropin-releasing factor (CRF) antagonist suppresses stress-induced locomotor activity in an amphibian. Lowry, C.A., Moore, F.L. Hormones and behavior. (1991) [Pubmed]
  3. 7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system. Matsunaga, M., Ukena, K., Baulieu, E.E., Tsutsui, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Conservation of fibroblast growth factor function in lens regeneration. Del Rio-Tsonis, K., Jung, J.C., Chiu, I.M., Tsonis, P.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Induction of ocular tumor by nickel subsulfide in the Japanese common newt, Cynops pyrrhogaster. Okamoto, M. Cancer Res. (1987) [Pubmed]
  6. Different regulation of T-box genes Tbx4 and Tbx5 during limb development and limb regeneration. Khan, P., Linkhart, B., Simon, H.G. Dev. Biol. (2002) [Pubmed]
  7. Pigment cell pattern formation in Taricha torosa: the role of the extracellular matrix in controlling pigment cell migration and differentiation. Tucker, R.P., Erickson, C.A. Dev. Biol. (1986) [Pubmed]
  8. Prolactin induces apoptosis in the penultimate spermatogonial stage of the testes in Japanese red-bellied newt (Cynops pyrrhogaster). Yazawa, T., Yamamoto, T., Abé, S. Endocrinology (2000) [Pubmed]
  9. Arginine vasotocin induces sexual behavior of newts by acting on cells in the brain. Moore, F.L., Miller, L.J. Peptides (1983) [Pubmed]
  10. Rapid corticosterone-induced impairment of amplectic clasping occurs in the spinal cord of roughskin newts (taricha granulosa). Lewis, C.M., Rose, J.D. Hormones and behavior. (2003) [Pubmed]
  11. Neuroanatomical distribution of cannabinoid receptor gene expression in the brain of the rough-skinned newt, Taricha granulosa. Hollis, D.M., Coddington, E.J., Moore, F.L. Brain Behav. Evol. (2006) [Pubmed]
  12. Comparative plasma levels of androgens and 17 beta-estradiol in the diploid and triploid newt, Pleurodeles waltl. Cayrol, C., Garnier, D.H., Deparis, P. Gen. Comp. Endocrinol. (1985) [Pubmed]
  13. Hox C6 expression during development and regeneration of forelimbs in larval Notophthalmus viridescens. Khan, P.A., Tsilfidis, C., Liversage, R.A. Dev. Genes Evol. (1999) [Pubmed]
  14. Autoradiographic characterization of binding sites labelled with vasopressin in the brain of a urodele amphibian. Tripp, S.K., Moore, F.L. Neuroendocrinology (1988) [Pubmed]
  15. New translation system of mRNA coding for neurotransmitter receptors using oocytes of the newt, Cynops pyrrhogaster. Kobayashi, S., Iio, H., Aoshima, H. Brain Res. (1986) [Pubmed]
  16. Potency of mixtures of general anaesthetic agents. Clarke, R.F., Daniels, S., Harrison, C.B., Jordan, M.J., Paton, W.D., Smith, E.B., Smith, R.A. British journal of anaesthesia. (1978) [Pubmed]
  17. Neuroanatomical distribution of androgen and estrogen receptor-immunoreactive cells in the brain of the male roughskin newt. Davis, G.A., Moore, F.L. J. Comp. Neurol. (1996) [Pubmed]
  18. Antibodies against different forms of GnRH distinguish different populations of cells and axonal pathways in a urodele amphibian, Taricha granulosa. Muske, L.E., Moore, F.L. J. Comp. Neurol. (1994) [Pubmed]
  19. Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques. Lowry, C.A., Richardson, C.F., Zoeller, T.R., Miller, L.J., Muske, L.E., Moore, F.L. J. Comp. Neurol. (1997) [Pubmed]
  20. Effect of prolactin and androgen on the expression of the female-attracting pheromone silefrin in the abdominal gland of the newt, Cynops ensicauda. Iwata, T., Kawahara, G., Yamamoto, K., Zhou, C.J., Nakajo, S., Shioda, S., Kikuyama, S. Biol. Reprod. (2000) [Pubmed]
  21. Neuroendocrinology of context-dependent stress responses: vasotocin alters the effect of corticosterone on amphibian behaviors. Coddington, E., Moore, F.L. Hormones and behavior. (2003) [Pubmed]
  22. Expression of FGF2 in the limb blastema of two Salamandridae correlates with their regenerative capability. Giampaoli, S., Bucci, S., Ragghianti, M., Mancino, G., Zhang, F., Ferretti, P. Proc. Biol. Sci. (2003) [Pubmed]
  23. Localization of prolactin receptor in the newt brain. Hasunuma, I., Toyoda, F., Yamamoto, K., Yamashita, M., Kikuyama, S. Cell Tissue Res. (2005) [Pubmed]
  24. Expression of prolactin receptor mRNA in the abdominal gland of the newt Cynops ensicauda. Matsukawa, H., Hasunuma, I., Kato, T., Yamamoto, K., Miura, S., Fujita, T., Kikuyama, S. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
  25. Behaviroal, pharmacological, and molecular characterization of an amphibian cannabinoid receptor. Soderstrom, K., Leid, M., Moore, F.L., Murray, T.F. J. Neurochem. (2000) [Pubmed]
  26. Breeding condition, temperature, and the regulation of salt and water by pituitary hormones in the red-spotted newt, Notophthalmus viridescens. Brown, P.S., Brown, S.C., Bisceglio, I.T., Lemke, S.M. Gen. Comp. Endocrinol. (1983) [Pubmed]
  27. Female-attracting pheromone in newt cloacal glands. Kikuyama, S., Toyoda, F., Yamamoto, K., Tanaka, S., Hayashi, H. Brain Res. Bull. (1997) [Pubmed]
  28. Bioengineered human growth hormone supports limb regeneration in the hypophysectomized newt Notophthalmus viridescens. Landesman, R.H., Copeland, K.C. J. Exp. Zool. (1988) [Pubmed]
  29. Neurotrophic effects of beta endorphin C-terminal tetrapeptide (MPF). Morley, J.S., Ensor, D.M. Neuropeptides (1986) [Pubmed]
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