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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Adenosine induces dormancy in starfish blastulae.

External application of 50 micrograms ml-1 adenosine inhibits development of the starfish Asterina pectinifera at the 256-cell stage when all the embryonic cells differentiate to epithelial cells. Intracellular concentration of adenosine in the adenosine-treated embryo is 2.7 times higher than those of the normal embryo whereas the contents of ATP, ADP, AMP and adenosine 3',5'-monophosphate are the same for both embryos. Adenosine causes more than 95% reduction in the rate of protein, DNA and RNA syntheses. By returning the embryo to normal sea water, macromolecular synthesis restarts and the embryo develops to the bipinnaria stage.[1]


  1. Adenosine induces dormancy in starfish blastulae. Tsuchimori, N., Miyashiro, S., Shibai, H., Ikegami, S. Development (1988) [Pubmed]
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