The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.
The proteasome is a multicatalytic proteinase complex composed of nonidentical protein subunits. We have isolated a cDNA clone encoding the 35 kd proteasome subunit of Drosophila melanogaster and propose the designation PROS-35 for the corresponding gene. The deduced amino acid sequence reveals a region of striking homology to a tyrosine phosphorylation site of viral and cellular proteins suggesting a potential regulatory function for the 35 kd subunit within the proteinase complex. Immunocytochemical experiments reveal a tissue-dependent differential distribution of the proteasome between the nucleus and cytoplasm. In addition developmental analysis shows that the proteasome is highly expressed in the CNS of stage-16 embryos and in cardia, ventriculus and ovaries of adult flies. These data suggest a tissue- and development-dependent distribution of the proteasome in D. melanogaster.[1]References
- The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. Haass, C., Pesold-Hurt, B., Multhaup, G., Beyreuther, K., Kloetzel, P.M. EMBO J. (1989) [Pubmed]
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