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Gene Review

Prosalpha5  -  Proteasome alpha5 subunit

Drosophila melanogaster

Synonyms: 154644_at, Alpha-5, CG10938, Dmel\CG10938, PRCZ, ...
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High impact information on ProsMA5


Biological context of ProsMA5


Other interactions of ProsMA5

  • To address the functional role of S13, we combined double-stranded RNA interference (RNAi) against the Drosophila proteasome subunit DmS13 with expression of wild-type and mutant forms of the homologous human gene, HS13 [10].
  • Cloning of two plant cDNAs encoding a beta-type proteasome subunit and a transformer-2-like SR-related protein: early induction of the corresponding genes in tobacco cells treated with cryptogein [7].

Analytical, diagnostic and therapeutic context of ProsMA5


  1. The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. Haass, C., Pesold-Hurt, B., Multhaup, G., Beyreuther, K., Kloetzel, P.M. EMBO J. (1989) [Pubmed]
  2. Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage. Schweisguth, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit. Saville, K.J., Belote, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Identification and characterization of a Drosophila proteasome regulatory network. Lundgren, J., Masson, P., Mirzaei, Z., Young, P. Mol. Cell. Biol. (2005) [Pubmed]
  5. A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. Neuburger, P.J., Saville, K.J., Zeng, J., Smyth, K.A., Belote, J.M. Genetics (2006) [Pubmed]
  6. Anopheles stephensi Dox-A2 shares common ancestry with genes from distant groups of eukaryotes encoding a 26S proteasome subunit and is in a conserved gene cluster. Garvey, C.F., Malcolm, C.A. J. Mol. Evol. (2000) [Pubmed]
  7. Cloning of two plant cDNAs encoding a beta-type proteasome subunit and a transformer-2-like SR-related protein: early induction of the corresponding genes in tobacco cells treated with cryptogein. Petitot, A.S., Blein, J.P., Pugin, A., Suty, L. Plant Mol. Biol. (1997) [Pubmed]
  8. Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. Trachtulec, Z., Hamvas, R.M., Forejt, J., Lehrach, H.R., Vincek, V., Klein, J. Genomics (1997) [Pubmed]
  9. Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Ma, J., Katz, E., Belote, J.M. Insect Mol. Biol. (2002) [Pubmed]
  10. Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Lundgren, J., Masson, P., Realini, C.A., Young, P. Mol. Cell. Biol. (2003) [Pubmed]
  11. Molecular cloning and characterization of a gene encoding the 29-kDa proteasome subunit from Trypanosoma cruzi. Bartholomeu, D.C., Batista, J.A., Vainstein, M.H., Lima, B.D., de Sá, M.C. Mol. Genet. Genomics (2001) [Pubmed]
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