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Sopta, M. et al.

Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.

RAP30/74 is a heteromeric general transcription initiation factor which binds to RNA polymerase II. Here we report that preparations of RAP30/74 contain an ATP-dependent DNA helicase whose probable function is to melt the DNA at transcriptional start sites. The sequence of the RAP30 subunit of RAP30/74 indicates that RAP30 may be distantly related to bacterial sigma factors.[1]

References

Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II. Sopta, M., Burton, Z.F., Greenblatt, J. Nature (1989) [Pubmed]

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