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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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McNerney, R. et al.

Changes in mRNA levels of poly(ADP-ribose) polymerase during activation of human lymphocytes.

The level of mRNA encoding the nuclear enzyme poly(ADP-ribose) polymerase (ADP-ribosyltransferase, EC 2.4.2.30) was found to be very low in quiescent human lymphocytes and to increase at least 10-fold between 1 and 2 dyas after stimulation with the mitogen phytohaemagglutinin, staying high for several days thereafter. This increase was inhibited by 3-methoxybenzamide (a competitive inhibitor of poly(ADP-ribose) polymerase) but was not affected significantly by aphidicolin. Incubation of activated cells with cycloheximide for 2 h increased the expression slightly. These data demonstrate that, during lymphocyte activation, the level of mRNA of the poly(ADP-ribose) polymerase gene correlates with, and hence is presumably responsible for, the increase in poly(ADP-ribose) polymerase protein detectable by enzyme assay or immunochemistry.[1]

References

Changes in mRNA levels of poly(ADP-ribose) polymerase during activation of human lymphocytes. McNerney, R., Tavasolli, M., Shall, S., Brazinski, A., Johnstone, A. Biochim. Biophys. Acta (1989) [Pubmed]

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