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Gene Review

ART1  -  ADP-ribosyltransferase 1

Homo sapiens

Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1, ART2, ARTC1, CD296, GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1, ...
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Disease relevance of ART1


Psychiatry related information on ART1


High impact information on ART1


Chemical compound and disease context of ART1


Biological context of ART1


Anatomical context of ART1

  • We reported that ART1, a mammalian ADP-ribosyltransferase, present in epithelial cells lining the human airway, modified HNP-1, altering its function [1].
  • When measuring expression of the mRNA of ART1, 3, 4 and 5, only ART3 mRNA was detected in unstimulated monocytes [21].
  • ADP-ribosyltransferase-specific modification of human neutrophil peptide-1 [1].
  • In skeletal muscle and lymphocytes, ART1 modifies specific members of the integrin family of adhesion molecules, suggesting that ADP-ribosylation affects cell-matrix or cell-cell interactions [22].
  • Fibroblasts expressing human ART1 at the cell surface showed reduced mitogenic responses to PDGF-BB, but not to PDGF-AA [18].

Associations of ART1 with chemical compounds


Regulatory relationships of ART1


Other interactions of ART1


Analytical, diagnostic and therapeutic context of ART1


  1. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. Paone, G., Stevens, L.A., Levine, R.L., Bourgeois, C., Steagall, W.K., Gochuico, B.R., Moss, J. J. Biol. Chem. (2006) [Pubmed]
  2. Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation. Koch-Nolte, F., Glowacki, G., Bannas, P., Braasch, F., Dubberke, G., Ortolan, E., Funaro, A., Malavasi, F., Haag, F. Cell. Immunol. (2005) [Pubmed]
  3. Alu-polymerase chain reaction genomic fingerprinting technique identifies multiple genetic loci associated with pancreatic tumourigenesis. McKie, A.B., Iwamura, T., Leung, H.Y., Hollingsworth, M.A., Lemoine, N.R. Genes Chromosomes Cancer (1997) [Pubmed]
  4. Characterization of NAD:arginine ADP-ribosyltransferases. Moss, J., Balducci, E., Cavanaugh, E., Kim, H.J., Konczalik, P., Lesma, E.A., Okazaki, I.J., Park, M., Shoemaker, M., Stevens, L.A., Zolkiewska, A. Mol. Cell. Biochem. (1999) [Pubmed]
  5. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. Chaffin, K.E., Beals, C.R., Wilkie, T.M., Forbush, K.A., Simon, M.I., Perlmutter, R.M. EMBO J. (1990) [Pubmed]
  6. Nursing diagnosis by computers: an application of neural networks. Harvey, R.M. Nursing diagnosis : ND : the official journal of the North American Nursing Diagnosis Association. (1993) [Pubmed]
  7. Botulinum C2 toxin ADP-ribosylates actin. Aktories, K., Bärmann, M., Ohishi, I., Tsuyama, S., Jakobs, K.H., Habermann, E. Nature (1986) [Pubmed]
  8. Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. Pautsch, A., Vogelsgesang, M., Tränkle, J., Herrmann, C., Aktories, K. EMBO J. (2005) [Pubmed]
  9. The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. Ratts, R., Zeng, H., Berg, E.A., Blue, C., McComb, M.E., Costello, C.E., vanderSpek, J.C., Murphy, J.R. J. Cell Biol. (2003) [Pubmed]
  10. Microinjection of recombinant p21rho induces rapid changes in cell morphology. Paterson, H.F., Self, A.J., Garrett, M.D., Just, I., Aktories, K., Hall, A. J. Cell Biol. (1990) [Pubmed]
  11. DNA repair dependent NAD+ metabolism is impaired in cells from patients with Fanconi's anemia. Klocker, H., Auer, B., Hirsch-Kauffmann, M., Altmann, H., Burtscher, H.J., Schweiger, M. EMBO J. (1983) [Pubmed]
  12. Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. Kaslow, H.R., Schlotterbeck, J.D., Mar, V.L., Burnette, W.N. J. Biol. Chem. (1989) [Pubmed]
  13. Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis. Barth, H., Preiss, J.C., Hofmann, F., Aktories, K. J. Biol. Chem. (1998) [Pubmed]
  14. Eukaryotic mono(ADP-ribosyl)transferase that ADP-ribosylates GTP-binding regulatory Gi protein. Tanuma, S., Kawashima, K., Endo, H. J. Biol. Chem. (1988) [Pubmed]
  15. The spvB gene-product of the Salmonella enterica virulence plasmid is a mono(ADP-ribosyl)transferase. Otto, H., Tezcan-Merdol, D., Girisch, R., Haag, F., Rhen, M., Koch-Nolte, F. Mol. Microbiol. (2000) [Pubmed]
  16. Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Burnette, W.N., Mar, V.L., Platler, B.W., Schlotterbeck, J.D., McGinley, M.D., Stoney, K.S., Rohde, M.F., Kaslow, H.R. Infect. Immun. (1991) [Pubmed]
  17. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki, G., Braren, R., Cetkovic-Cvrlje, M., Leiter, E.H., Haag, F., Koch-Nolte, F. Gene (2001) [Pubmed]
  18. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. Saxty, B.A., Yadollahi-Farsani, M., Upton, P.D., Johnstone, S.R., MacDermot, J. Br. J. Pharmacol. (2001) [Pubmed]
  19. Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling. Seman, M., Adriouch, S., Haag, F., Koch-Nolte, F. Current medicinal chemistry. (2004) [Pubmed]
  20. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. Grahnert, A., Friedrich, M., Engeland, K., Hauschildt, S. Biochim. Biophys. Acta (2005) [Pubmed]
  21. Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Grahnert, A., Friedrich, M., Pfister, M., Haag, F., Koch-Nolte, F., Hauschildt, S. Biochem. J. (2002) [Pubmed]
  22. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. Okazaki, I.J., Moss, J. Annu. Rev. Nutr. (1999) [Pubmed]
  23. Polymorphic forms of human ADP-ribosyltransferase-1 differences in their catalytic activities revealed by labeling of membrane-associated substrates. Yadollahi-Farsani, M., Kefalas, P., Saxty, B.A., MacDermot, J. Eur. J. Biochem. (1999) [Pubmed]
  24. Selective expression of RT6 superfamily in human bronchial epithelial cells. Balducci, E., Horiba, K., Usuki, J., Park, M., Ferrans, V.J., Moss, J. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  25. Cloning and characterization of the human ADP-ribosylation factor 4 gene. Lebeda, R.A., Haun, R.S. Gene (1999) [Pubmed]
  26. Uncoupling Crk signal transduction by Pseudomonas exoenzyme T. Deng, Q., Sun, J., Barbieri, J.T. J. Biol. Chem. (2005) [Pubmed]
  27. Minireview: enzymatic properties of ribosome-inactivating proteins (RIPs) and related toxins. Fong, W.P., Wong, R.N., Go, T.T., Yeung, H.W. Life Sci. (1991) [Pubmed]
  28. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. Kefalas, P., Saxty, B., Yadollahi-Farsani, M., MacDermot, J. Eur. J. Biochem. (1999) [Pubmed]
  29. High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Huang, M., Dinney, C.P., Lin, X., Lin, J., Grossman, H.B., Wu, X. Cancer Epidemiol. Biomarkers Prev. (2007) [Pubmed]
  30. Inhibition of chemotaxis in A7r5 rat smooth muscle cells by a novel panel of inhibitors. Saxty, B.A., Yadollahi-Farsani, M., Kefalas, P., Paul, S., MacDermot, J. Br. J. Pharmacol. (1998) [Pubmed]
  31. Molecular characterization of the in vitro activation of pertussis toxin by ATP. Krueger, K.M., Barbieri, J.T. J. Biol. Chem. (1993) [Pubmed]
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