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Stuck, A.E. et al.

Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis.

1. Plasma concentrations of acitretin and its metabolite (13-cis acitretin) were measured in six patients on haemodialysis and six subjects without renal failure following a single oral dose of 50 mg of acitretin. 2. The mean areas under the plasma concentration vs time curves of acitretin and its metabolite were about 50% lower in patients on haemodialysis. 3. No retinoids were detectable in the dialysate.[1]

References

Pharmacokinetics of acitretin and its 13-cis metabolite in patients on haemodialysis. Stuck, A.E., Brindley, C.J., Busslinger, A., Frey, F.J. British journal of clinical pharmacology. (1989) [Pubmed]

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