Disease relevance of Kidney Failure

• BACKGROUND: Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death [1].
• Thiopental-related immune hemolytic anemia and renal failure. Specific involvement of red-cell antigen I [2].
• Nephronophthisis (NPHP), a group of autosomal recessive cystic kidney disorders, is the most common genetic cause of progressive renal failure in children and young adults [3].
• Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis [4].
• Irreversible renal failure after indomethacin in steroid-resistant nephrosis [5].

Psychiatry related information on Kidney Failure

• Four weeks postnatally, he had an episode of transient renal failure followed by lethargy leading to coma [6].
• Secretion of growth hormone (GH) is excessive in acromegaly, but also in a number of other pathological states such as anorexia nervosa, insulin-dependent diabetes mellitus (IDDM), liver cirrhosis, depression, renal failure and GH-insensitivity syndrome [7].
• Ammonia and methylamine (MET) are endogenous compounds increased during liver and renal failure, Alzheimer's disease, vascular dementia and diabetes, where they alter some neurobehavioural functions probably acting as potassium channel blockers [8].
• A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid [9].
• Heroin addiction, renal failure, and methadone maintenance: a follow-up report [10].

High impact information on Kidney Failure

• These compensatory changes are adequate to maintain electrolyte and water homeostasis until severe renal failure ensures (GFR less than 20% of normal) [11].
• Fluid secretion in the nephron: Relation to renal failure [12].
• Mutations of the ciliary protein inversin cause nephronophthisis type II, an autosomal recessive cystic kidney disease characterized by extensive renal cysts, situs inversus and renal failure [13].
• Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools [14].
• Impairment of this pathway may enhance spontaneous mutation frequency and activate p53-dependent apoptotic pathway(s) in vivo, causing severe renal failure, growth retardation and early mortality [14].

Chemical compound and disease context of Kidney Failure

• Of the 17 children who received adequate treatment, none had renal failure; their mean creatinine clearance was 57 +/- 20 ml per minute per 1.73 m2 at 8.3 +/- 3.8 years of age [15].
• Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs [16].
• The use of deferoxamine in the management of aluminium accumulation in bone in patients with renal failure [17].
• Prolonged neuromuscular blockade after the termination of long-term treatment with vecuronium is associated with metabolic acidosis, elevated plasma magnesium concentrations, female sex, and probably more important, the presence of renal failure and high plasma concentrations of 3-desacetylvecuronium [18].
• For patients taking oral prednisone alone, the probability of renal failure began to increase substantially after five years of observation [19].

Biological context of Kidney Failure

• A gene locus of a fourth variant of aBS called BSND, which in contrast to the other forms is associated with sensorineural deafness (SND) and renal failure, has been mapped to chromosome 1p [20].
• The renal clearance of iothalamate sodium I 125, identical to that of inulin, permits measurement of glomerular filtration rate with a single injection in varying degrees of renal failure [21].
• The X-linked form of Alport disease, caused by mutations in the COL4A5 or the COL4A6 gene, usually leads to terminal renal failure in males, while affected females have a more variable and moderate phenotype [22].
• All affected animals had excessive complement activation, revealed as low plasma C3, elevated plasma terminal complement complex, and massive deposits of complement in the renal glomeruli, and eventually died of renal failure within 11 wk of birth [23].
• BACKGROUND: Low-dose dopamine is commonly administered to critically ill patients in the belief that it reduces the risk of renal failure by increasing renal blood flow [24].

Anatomical context of Kidney Failure

• The clinical syndrome included renal failure, hepatitis, pancreatitis, central nervous system impairment, coma, and death [25].
• Twelve patients with severe renal failure and intercurrent urinary tract infections were treated with either ampicillin trihydrate, 500 mg four times a day, or trimethoprim-sulfamethoxazole, two tablets (80 mg trimethoprim, 400 mg sulfamethoxazole) twice a day [26].
• Myoblast transfer of human erythropoietin gene in a mouse model of renal failure [27].
• Mesangial cell (MC) proliferation and extracellular matrix expansion are involved in the pathogenesis of glomerulosclerosis and renal failure [28].
• MEASUREMENTS: 1) Renal remission (defined as < 10 dysmorphic erythrocytes per high-power field, the absence of cellular casts, and excretion of < 1 g of protein per day without doubling of the serum creatinine level), 2) prevention of doubling of the serum creatinine level, and 3) prevention of renal failure requiring dialysis [29].

Gene context of Kidney Failure

• Cardiac defects and renal failure in mice with targeted mutations in Pkd2 [30].
• Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure [20].
• Autosomal recessive polycystic kidney disease (ARPKD) is an inherited cystic disorder that produces renal failure in infants and children and is caused by mutations of PKHD1 [31].
• We analyzed Lcn2-/- mice using a mouse model for severe renal failure and could not detect any significant differences compared with their WT littermates [32].
• These data suggested that severe secondary ADAMTS13 deficiency can be associated with sepsis-induced DIC and may contribute to the development of renal failure [33].

Analytical, diagnostic and therapeutic context of Kidney Failure

• Development of renal failure in such a patient provided the opportunity to test whether or not this metabolic defect could be reversed by a renal allograft, which contains the missing enzyme and has potential for glucose synthesis [34].
• Septic encephalopathic patients had elevated serum urea nitrogen and bilirubin levels, increased APACHE II scores, and a higher incidence of renal failure [35].
• To elucidate the metabolism of islet amyloid polypeptide (IAPP) with respect to a possible renal elimination we investigated IAPP levels in 20 lean, nondiabetic patients with renal failure maintained on chronic hemodialysis (HD) and in 20 healthy controls [36].
• Collection of 31P NMR spectra from hearts of renal failure and control animals during 30 min normoxic Langendorff perfusion showed that basal phosphocreatine was reduced by 32% to 4.7 mumol/g wet wt (P < 0.01) and the phosphocreatine to ATP ratio was reduced by 32% (P < 0.01) in uremic hearts [37].
• Allergic reactions to the polymeric glucose-based peritoneal dialysis fluid icodextrin in patients with renal failure [38].

References