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MeSH Review

Kidney Failure

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Disease relevance of Kidney Failure


Psychiatry related information on Kidney Failure


High impact information on Kidney Failure

  • These compensatory changes are adequate to maintain electrolyte and water homeostasis until severe renal failure ensures (GFR less than 20% of normal) [11].
  • Fluid secretion in the nephron: Relation to renal failure [12].
  • Mutations of the ciliary protein inversin cause nephronophthisis type II, an autosomal recessive cystic kidney disease characterized by extensive renal cysts, situs inversus and renal failure [13].
  • Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools [14].
  • Impairment of this pathway may enhance spontaneous mutation frequency and activate p53-dependent apoptotic pathway(s) in vivo, causing severe renal failure, growth retardation and early mortality [14].

Chemical compound and disease context of Kidney Failure


Biological context of Kidney Failure


Anatomical context of Kidney Failure


Gene context of Kidney Failure


Analytical, diagnostic and therapeutic context of Kidney Failure


  1. Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. Brent, J., McMartin, K., Phillips, S., Burkhart, K.K., Donovan, J.W., Wells, M., Kulig, K. N. Engl. J. Med. (1999) [Pubmed]
  2. Thiopental-related immune hemolytic anemia and renal failure. Specific involvement of red-cell antigen I. Habibi, B., Basty, R., Chodez, S., Prunat, A. N. Engl. J. Med. (1985) [Pubmed]
  3. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Olbrich, H., Fliegauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. Nat. Genet. (2003) [Pubmed]
  4. Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis. Kovesi, T.A., Swartz, R., MacDonald, N. N. Engl. J. Med. (1998) [Pubmed]
  5. Irreversible renal failure after indomethacin in steroid-resistant nephrosis. Kleinknecht, C., Broyer, M., Gubler, M.C., Palcoux, J.B. N. Engl. J. Med. (1980) [Pubmed]
  6. November 1996--premature baby with lethargy and coma. Hevner, R., Sobel, R.A. Brain Pathol. (1997) [Pubmed]
  7. Involvement of brain catecholamines and acetylcholine in growth hormone hypersecretory states. Pathophysiological, diagnostic and therapeutic implications. Müller, E.E., Rolla, M., Ghigo, E., Belliti, D., Arvat, E., Andreoni, A., Torsello, A., Locatelli, V., Camanni, F. Drugs (1995) [Pubmed]
  8. Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype. Pirisino, R., Ghelardini, C., Pacini, A., Galeotti, N., Raimondi, L. Br. J. Pharmacol. (2004) [Pubmed]
  9. Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. Kottlors, M., Jaksch, M., Ketelsen, U.P., Weiner, S., Glocker, F.X., Lücking, C.H. Neuromuscul. Disord. (2001) [Pubmed]
  10. Heroin addiction, renal failure, and methadone maintenance: a follow-up report. Charuvastra, V.C., Ouren, J., Powell, B. Drug and alcohol dependence. (1980) [Pubmed]
  11. Functional adaptation to reduction in renal mass. Hayslett, J.P. Physiol. Rev. (1979) [Pubmed]
  12. Fluid secretion in the nephron: Relation to renal failure. Grantham, J.J. Physiol. Rev. (1976) [Pubmed]
  13. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O.A., Jenny, A., Mlodzik, M., Polok, B., Driever, W., Obara, T., Walz, G. Nat. Genet. (2005) [Pubmed]
  14. Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Kimura, T., Takeda, S., Sagiya, Y., Gotoh, M., Nakamura, Y., Arakawa, H. Nat. Genet. (2003) [Pubmed]
  15. Improved renal function in children with cystinosis treated with cysteamine. Markello, T.C., Bernardini, I.M., Gahl, W.A. N. Engl. J. Med. (1993) [Pubmed]
  16. Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. Perneger, T.V., Whelton, P.K., Klag, M.J. N. Engl. J. Med. (1994) [Pubmed]
  17. The use of deferoxamine in the management of aluminium accumulation in bone in patients with renal failure. Malluche, H.H., Smith, A.J., Abreo, K., Faugere, M.C. N. Engl. J. Med. (1984) [Pubmed]
  18. Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo, V., Caldwell, J.E., Matthay, M.A., Sharma, M.L., Gruenke, L.D., Miller, R.D. N. Engl. J. Med. (1992) [Pubmed]
  19. Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. Austin, H.A., Klippel, J.H., Balow, J.E., le Riche, N.G., Steinberg, A.D., Plotz, P.H., Decker, J.L. N. Engl. J. Med. (1986) [Pubmed]
  20. Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Birkenhäger, R., Otto, E., Schürmann, M.J., Vollmer, M., Ruf, E.M., Maier-Lutz, I., Beekmann, F., Fekete, A., Omran, H., Feldmann, D., Milford, D.V., Jeck, N., Konrad, M., Landau, D., Knoers, N.V., Antignac, C., Sudbrak, R., Kispert, A., Hildebrandt, F. Nat. Genet. (2001) [Pubmed]
  21. Single subcutaneous injection of iothalamate sodium I 125 to measure glomerular filtration rate. Adefuin, P.Y., Gur, A., Siegel, N.J., Spencer, R.P., Hayslett, J.P. JAMA (1976) [Pubmed]
  22. Severe alport phenotype in a woman with two missense mutations in the same COL4A5 gene and preponderant inactivation of the X chromosome carrying the normal allele. Guo, C., Van Damme, B., Vanrenterghem, Y., Devriendt, K., Cassiman, J.J., Marynen, P. J. Clin. Invest. (1995) [Pubmed]
  23. Hereditary porcine membranoproliferative glomerulonephritis type II is caused by factor H deficiency. Høgåsen, K., Jansen, J.H., Mollnes, T.E., Hovdenes, J., Harboe, M. J. Clin. Invest. (1995) [Pubmed]
  24. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Bellomo, R., Chapman, M., Finfer, S., Hickling, K., Myburgh, J. Lancet (2000) [Pubmed]
  25. Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. Acute Renal Failure Investigation Team. O'Brien, K.L., Selanikio, J.D., Hecdivert, C., Placide, M.F., Louis, M., Barr, D.B., Barr, J.R., Hospedales, C.J., Lewis, M.J., Schwartz, B., Philen, R.M., St Victor, S., Espindola, J., Needham, L.L., Denerville, K. JAMA (1998) [Pubmed]
  26. Urinary tract infections in patients with severe renal disease. Treatment with ampicillin and trimethoprim-sulfamethoxazole. Bennett, W.M., Craven, R. JAMA (1976) [Pubmed]
  27. Myoblast transfer of human erythropoietin gene in a mouse model of renal failure. Hamamori, Y., Samal, B., Tian, J., Kedes, L. J. Clin. Invest. (1995) [Pubmed]
  28. Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. Floege, J., Eng, E., Young, B.A., Alpers, C.E., Barrett, T.B., Bowen-Pope, D.F., Johnson, R.J. J. Clin. Invest. (1993) [Pubmed]
  29. Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized, controlled trial. Gourley, M.F., Austin, H.A., Scott, D., Yarboro, C.H., Vaughan, E.M., Muir, J., Boumpas, D.T., Klippel, J.H., Balow, J.E., Steinberg, A.D. Ann. Intern. Med. (1996) [Pubmed]
  30. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Wu, G., Markowitz, G.S., Li, L., D'Agati, V.D., Factor, S.M., Geng, L., Tibara, S., Tuchman, J., Cai, Y., Park, J.H., van Adelsberg, J., Hou, H., Kucherlapati, R., Edelmann, W., Somlo, S. Nat. Genet. (2000) [Pubmed]
  31. Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. Hiesberger, T., Bai, Y., Shao, X., McNally, B.T., Sinclair, A.M., Tian, X., Somlo, S., Igarashi, P. J. Clin. Invest. (2004) [Pubmed]
  32. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Berger, T., Togawa, A., Duncan, G.S., Elia, A.J., You-Ten, A., Wakeham, A., Fong, H.E., Cheung, C.C., Mak, T.W. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  33. Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Ono, T., Mimuro, J., Madoiwa, S., Soejima, K., Kashiwakura, Y., Ishiwata, A., Takano, K., Ohmori, T., Sakata, Y. Blood (2006) [Pubmed]
  34. Renal tranplantation in type 1 glycogenosis. Failure to improve glucose metabolism. Emmett, M., Narins, R.G. JAMA (1978) [Pubmed]
  35. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. Eidelman, L.A., Putterman, D., Putterman, C., Sprung, C.L. JAMA (1996) [Pubmed]
  36. Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion. Ludvik, B., Clodi, M., Kautzky-Willer, A., Schuller, M., Graf, H., Hartter, E., Pacini, G., Prager, R. J. Clin. Invest. (1994) [Pubmed]
  37. Impairment of cardiac function and energetics in experimental renal failure. Raine, A.E., Seymour, A.M., Roberts, A.F., Radda, G.K., Ledingham, J.G. J. Clin. Invest. (1993) [Pubmed]
  38. Allergic reactions to the polymeric glucose-based peritoneal dialysis fluid icodextrin in patients with renal failure. Goldsmith, D., Jayawardene, S., Sabharwal, N., Cooney, K. Lancet (2000) [Pubmed]
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