Disease relevance of Isoacitretin

• 1. Plasma concentrations of acitretin and its metabolite (13-cis acitretin) were measured in six patients on haemodialysis and six subjects without renal failure following a single oral dose of 50 mg of acitretin [1].

High impact information on Isoacitretin

• PATIENTS/METHODS: Eighty-six acitretin (Neotigason(R), Roche)-treated outpatients from three centres provided pre-dose (trough) samples for determining plasma concentrations of acitretin and its metabolites 13-cis-acitretin and etretinate [2].
• Glutathione catalysis of interconversion of acitretin and its 13-cis isomer isoacitretin [3].
• The maximum peak level and also the AUC (area under the concentration-time curve) value of all-trans-etretin in the embryos was 7-8 times higher than corresponding values for 13-cis-etretin, probably due to extensive transport of the trans-isomer and limited transport of the cis-isomer from maternal plasma to the embryos [4].

Associations of Isoacitretin with other chemical compounds

• Plasma concentrations of acitretin and its primary metabolite isoacitretin were quantified by reversed-phase HPLC [5].

Analytical, diagnostic and therapeutic context of Isoacitretin

• Concentrations of the parent compound and its main metabolite, 13-cis acitretin, were measured in serum and mature milk during the initial nine days of therapy, using reverse-phase high performance liquid chromatography [6].

References