Chemical Compound Review:
Acitretin (2E,4E,6E,8E)-9-(4-methoxy- 2,3,6-trimethyl...
Synonyms:
Etretin, Soriatane, Acitretina, Acitretine, Isoetretin, ...
- Remission of cutaneous T-cell lymphoma with combined calcitriol and acitretin. French, L.E., Ramelet, A.A., Saurat, J.H. Lancet (1994)
- Prevention of skin cancer and reduction of keratotic skin lesions during acitretin therapy in renal transplant recipients: a double-blind, placebo-controlled study. Bavinck, J.N., Tieben, L.M., Van der Woude, F.J., Tegzess, A.M., Hermans, J., ter Schegget, J., Vermeer, B.J. J. Clin. Oncol. (1995)
- Conversion of acitretin to etretinate in psoriatic patients is influenced by ethanol. Larsen, F.G., Jakobsen, P., Knudsen, J., Weismann, K., Kragballe, K., Nielsen-Kudsk, F. J. Invest. Dermatol. (1993)
- Acitretin is converted to etretinate only during concomitant alcohol intake. Grønhøj Larsen, F., Steinkjer, B., Jakobsen, P., Hjorter, A., Brockhoff, P.B., Nielsen-Kudsk, F. Br. J. Dermatol. (2000)
- Multiple cutaneous squamous carcinoma in a psoriatic associated with ciclosporin, alcohol abuse and ultraviolet radiation exposure which were suppressed by acitretin. Agnew, K.L., Bunker, C.B. Journal of the European Academy of Dermatology and Venereology : JEADV. (2003)
- Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. Young, H.S., Summers, A.M., Read, I.R., Fairhurst, D.A., Plant, D.J., Campalani, E., Smith, C.H., Barker, J.N., Detmar, M.J., Brenchley, P.E., Griffiths, C.E. J. Invest. Dermatol. (2006)
- Anti-proliferative effect of retinoids and interferon-alpha-2a on vaginal cell lines derived from squamous intra-epithelial lesions. Hietanen, S., Auvinen, E., Syrjänen, K., Syrjänen, S. Int. J. Cancer (1998)
- Regulation of the induction of ornithine decarboxylase in keratinocytes by retinoids. Zheng, Z.S., Xue, G.Z., Prystowsky, J.H. Biochem. J. (1995)
- Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. Raynaud, F., Gerbaud, P., Bouloc, A., Gorin, I., Anderson, W.B., Evain-Brion, D. J. Invest. Dermatol. (1993)
- Pharmacokinetics and therapeutic efficacy of retinoids in skin diseases. Larsen, F.G., Nielsen-Kudsk, F., Jakobsen, P., Weismann, K., Kragballe, K. Clinical pharmacokinetics. (1992)
- Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs. Wilhelm, K.P., Surber, C., Maibach, H.I. J. Invest. Dermatol. (1991)
- Systemic sequential therapy of psoriasis: a new paradigm for improved therapeutic results. Koo, J. J. Am. Acad. Dermatol. (1999)
- The effect of addition of calcipotriol ointment (50 micrograms/g) to acitretin therapy in psoriasis. van de Kerkhof, P.C., Cambazard, F., Hutchinson, P.E., Haneke, E., Wong, E., Souteyrand, P., Damstra, R.J., Combemale, P., Neumann, M.H., Chalmers, R.J., Olsen, L., Revuz, J. Br. J. Dermatol. (1998)
- Multiple squamous cell carcinomas in a psoriatic patient following high-dose photochemotherapy and cyclosporin treatment: response to long-term acitretin maintenance. van de Kerkhof, P.C., de Rooij, M.J. Br. J. Dermatol. (1997)
- Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. Zouboulis, C.C., Korge, B., Akamatsu, H., Xia, L.Q., Schiller, S., Gollnick, H., Orfanos, C.E. J. Invest. Dermatol. (1991)
- Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Armstrong, J.L., Ruiz, M., Boddy, A.V., Redfern, C.P., Pearson, A.D., Veal, G.J. Br. J. Cancer (2005)
- The pharmacokinetics of acitretin and its 13-cis-metabolite in psoriatic patients. Larsen, F.G., Jakobsen, P., Eriksen, H., Grønhøj, J., Kragballe, K., Nielsen-Kudsk, F. Journal of clinical pharmacology. (1991)
- Food increases the bioavailability of acitretin. McNamara, P.J., Jewell, R.C., Jensen, B.K., Brindley, C.J. Journal of clinical pharmacology. (1988)
- Human dermal fibroblasts modulate the effects of retinoids on epidermal growth. Sanquer, S., Coulomb, B., Lebreton, C., Dubertret, L. J. Invest. Dermatol. (1990)
- Synthetic retinoids inhibit the antigen presenting properties of epidermal cells in vitro. Dupuy, P., Bagot, M., Heslan, M., Dubertret, L. J. Invest. Dermatol. (1989)
- Effect of retinoids on nuclear retinoic acid receptors mRNA in adipose tissue of retinol-deficient rats. Riaz-ul-Haq, n.u.l.l., Chytil, F. J. Lipid Res. (1992)
- Retinoids and state of differentiation modulate CRABP II gene expression in a skin equivalent. Sanquer, S., Eller, M.S., Gilchrest, B.A. J. Invest. Dermatol. (1993)
- Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol. Hettmannsperger, U., Detmar, M., Owsianowski, M., Tenorio, S., Kammler, H.J., Orfanos, C.E. J. Invest. Dermatol. (1992)
- Therapy with a synthetic retinoid--(Ro 10-1670) etretin--increases the cellular retinoic acid-binding protein in nonlesional psoriatic skin. Siegenthaler, G., Saurat, J.H. J. Invest. Dermatol. (1986)
- In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Knights, K.M., Gasser, R., Klemisch, W. Biochem. Pharmacol. (2000)
- Phenotypic/genotypic correlations in patients with epidermolytic hyperkeratosis and the effects of retinoid therapy on keratin expression. Virtanen, M., Gedde-Dahl, T., Mörk, N.J., Leigh, I., Bowden, P.E., Vahlquist, A. Acta Derm. Venereol. (2001)
- The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of hallopeau. Kazinski, K., Joyce, K.M., Hodson, D. Journal of drugs in dermatology : JDD. (2005)
- P160L mutation in the Ca(2+) ATPase 2A domain in a patient with severe Darier disease. Godic, A., Glavac, D., Korosec, B., Miljković, J., Potocnik, M., Kansky, A. Dermatology (Basel) (2004)
- The state of differentiation of cultured human keratinocytes determines the level of intercellular adhesion molecule-1 (ICAM-1) expression induced by gamma interferon. Kashihara-Sawami, M., Norris, D.A. J. Invest. Dermatol. (1992)
- Prospective randomized multicenter clinical trial on the use of interferon -2a plus acitretin versus interferon -2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II. Stadler, R., Otte, H.G., Luger, T., Henz, B.M., Kühl, P., Zwingers, T., Sterry, W. Blood (1998)
- Combined treatment of psoriasis with acitretin and UVB phototherapy compared with acitretin alone and UVB alone. Iest, J., Boer, J. Br. J. Dermatol. (1989)
- High-performance liquid chromatography determination of acitretin in plasma and its application to a pharmacokinetic study in human subjects. Surber, C., Laugier, J.P., Geiger, J.M., Bun, H., Durand, A., Maibach, H.I. Pharm. Res. (1992)