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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Active oxygen contributes to the major part of chromosomal aberrations in V79 Chinese hamster cells exposed to N-hydroxy-2-naphthylamine.

N-hydroxy-2-naphthylamine (NOH-2NA), an active metabolite of human occupational bladder carcinogens, induced, in V79 Chinese hamster cells, chromosomal aberrations which were suppressed in the presence of catalase and/or superoxide dismutase. The induction of the aberrations was more efficient in a more basic pH in parallel with the generation of hydrogen peroxide from NOH-2NA. The possible role of the oxidation product of NOH-2NA in the induction of the aberrations is discussed.[1]

References

  1. Active oxygen contributes to the major part of chromosomal aberrations in V79 Chinese hamster cells exposed to N-hydroxy-2-naphthylamine. Ochi, T., Kaneko, M. Free Radic. Res. Commun. (1989) [Pubmed]
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