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Chemical Compound Review:

CCRIS 426 N-naphthalen-2-ylhydroxylamine

Synonyms: CHEMBL85032, AC1L2BAD, AC1Q7DJR, LS-77450, AR-1K7157, ...

Kaneko, M. et al., Nakayama, T. et al., Kaneko, M. et al., Ochi, T. et al.

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Disease relevance of beta-Naphthylhydroxylamine

Active oxygen contributes to the major part of chromosomal aberrations in V79 Chinese hamster cells exposed to N-hydroxy-2-naphthylamine [1].

High impact information on beta-Naphthylhydroxylamine

Exposure of DNA to N-hydroxy-2-naphthylamine in the presence of catalase and superoxide dismutase, which break down hydrogen peroxide and superoxide anions, respectively, inhibited the production of this base damage [2].
The DNA lesions induced by active oxygen species generated from N-hydroxy-2-naphthylamine were quantitated by the alkaline elution technique as single-strand breaks using cultured human-skin fibroblasts [3].
Repair of indirectly induced DNA damage in human skin fibroblasts treated with N-hydroxy-2-naphthylamine [3].
Incubation of 2-naphthylamine (2-NA) with rat liver microsomes fortified with NADPH resulted in the formation of two types of free radicals which were identified as being due to N-hydroxy-2-naphthylamine and 2-amino-1-naphthol [4].

References

Active oxygen contributes to the major part of chromosomal aberrations in V79 Chinese hamster cells exposed to N-hydroxy-2-naphthylamine. Ochi, T., Kaneko, M. Free Radic. Res. Commun. (1989) [Pubmed]
Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody. Kaneko, M., Leadon, S.A. Cancer Res. (1986) [Pubmed]
Repair of indirectly induced DNA damage in human skin fibroblasts treated with N-hydroxy-2-naphthylamine. Kaneko, M., Nagata, C., Kodama, M. Mutat. Res. (1985) [Pubmed]
Electron spin resonance study on the metabolism of 2-naphthylamine and 1-naphthylamine in rat liver microsomes. Nakayama, T., Kimura, T., Kodama, M., Nagata, C. Gann = Gan. (1982) [Pubmed]

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