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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Two NF1 translocations map within a 600-kilobase segment of 17q11.2.

Balanced translocations, each involving chromosome 17q11.2, have been described in two patients with von Recklinghausen neurofibromatosis ( NF1). To better localize the end points of these translocation events, and the NF1 gene ( NF1) itself, human cosmids were isolated and mapped in the immediate vicinity of NF1. One cosmid probe, c11-1F10, demonstrated that both translocation breakpoints, and presumably NF1, are contained within a 600-kilobase Nru I fragment.[1]


  1. Two NF1 translocations map within a 600-kilobase segment of 17q11.2. O'Connell, P., Leach, R., Cawthon, R.M., Culver, M., Stevens, J., Viskochil, D., Fournier, R.E., Rich, D.C., Ledbetter, D.H., White, R. Science (1989) [Pubmed]
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