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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Impaired ACTH and beta-endorphin response to sauna-induced hyperthermia in heroin addicts.

To evaluate the responses of circulating beta-endorphin, met-enkephalin and ACTH to sauna-induced hyperthermia, 8 male heroin addicts recently admitted to a therapeutic community and 8 age-matched normal subjects were examined. Compared with control subjects, heroin addicts showed 1. A decrease of the basal levels of beta-endorphin; 2. Absence of the normal increase of beta-endorphin and ACTH after sauna; 3. A lower increase in systolic blood pressure. It is concluded that an impairment of the adaptive response to stress may be present in heroin addicts, even after a relatively short drug-free period (14 days).[1]

References

  1. Impaired ACTH and beta-endorphin response to sauna-induced hyperthermia in heroin addicts. Vescovi, P.P., Pedrazzoni, M., Gerra, G., Pioli, G., Maninetti, L., Michelini, M., Passeri, M. Acta Endocrinol. (1989) [Pubmed]
 
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