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Nevill, T.J. et al.

Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.

High-dose cytosine arabinoside may benefit patients with refractory acute leukemia. Peripheral nervous system disturbances caused by cytosine arabinoside have rarely been reported. We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside. Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.[1]

References

Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside. Nevill, T.J., Benstead, T.J., McCormick, C.W., Hayne, O.A. Am. J. Hematol. (1989) [Pubmed]

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