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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304).

A new polymorphic DNA marker U6.2, defining the locus DXS304, was recently isolated and mapped to the Xq27 region of the X chromosome. In the previous communication we describe a linkage study encompassing 16 fragile-X families and using U6.2 and five previously described polymorphic markers at Xq26-q28. One recombination event was observed between DXS304 and the fragile-X locus in 36 informative meioses. Combined with information from other reports, our results suggest the following order of the examined loci on Xq: cen-F9-DXS105-DXS98-FRAXA-DXS304-(DXS52-F8 -DXS15). The locus DXS304 is closely linked to FRAXA, giving a peak lod score of 5.86 at a corresponding recombination fraction of .00. On the basis of the present results, it is apparent that U6.2 is a useful probe for carrier and prenatal diagnosis in fragile-X families.[1]

References

  1. Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304). Dahl, N., Goonewardena, P., Malmgren, H., Gustavson, K.H., Holmgren, G., Seemanova, E., Annerén, G., Flood, A., Pettersson, U. Am. J. Hum. Genet. (1989) [Pubmed]
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