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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome.

The effect of gamma-hydroxybutyric acid (GHB) on ethanol withdrawal syndrome in alcoholics was investigated in a randomised double-blind study. Patients with withdrawal symptoms were treated either with GHB (orally in a syrup preparation) (11 patients) or with the syrup alone (12). GHB treatment (50 mg/kg) led to a prompt reduction in withdrawal symptoms, such as tremors, sweating, nausea, depression, anxiety, and restlessness. The only side-effect was dizziness. GHB may be useful in the management of alcohol withdrawal syndrome in man.[1]


  1. Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. Gallimberti, L., Canton, G., Gentile, N., Ferri, M., Cibin, M., Ferrara, S.D., Fadda, F., Gessa, G.L. Lancet (1989) [Pubmed]
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