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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The kinetics of papillotoxic doses of 3H-N-phenylanthranilic acid in rats.

N-phenylanthranilic acid (N-PAA; 4 mmol/kg/day p.o.) causes a diffuse renal papillary necrosis and a polyuria in 7 days. A single dose of 3H-N-PAA was widely distributed with second-order elimination kinetics, t1/2 +/- 50 h for stomach, heart, kidney, and bladder and t1/2 greater than or equal to 90 h for liver, spleen, muscle and lung. The estimated plasma t1/2 = 10.2 h, and over 75% was excreted via urine in 36 h and 13% via faeces in 72 h. In chronically cannulated animals 29% of N-PAA-derived material was in bile and 24% in urine at 36 h, which suggests enterohepatic circulation. Bile and urine contained several metabolites but no parent compound. Multiple doses for 8 and 16 days increased urinary N-PAA excretion to 90% in 36 h, but faecal contents decreased to 6-8% in 72 h and plasma t1/2 to less than or equal to 7.5 h.[1]


  1. The kinetics of papillotoxic doses of 3H-N-phenylanthranilic acid in rats. Whittingham, A., Delacruz, L., Gregg, N.J., Albores, A., Ijomah, P., Bach, P.H. Renal physiology and biochemistry. (1989) [Pubmed]
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