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Disease relevance of Polyuria


Psychiatry related information on Polyuria


High impact information on Polyuria

  • The secretion and action of vasopressin were studied both when the women had polyuria and polydipsia and later, when their water intake and urine volume were normal [11].
  • Thus, amiloride may provide a specific therapy for polyuria in lithium-treated patients while obviating the need for potassium supplementation in the treatment of this kind of polyuria [12].
  • We also find drug-induced polyuria in mrp1(-/-) mice, which correlates with the presence of mrp1 protein in the urinary collecting tubules, the major site of kidney water reabsorption [13].
  • In contrast, heterozygous mice expressing a mutation that truncates the AVP precursor (C67X) exhibited polyuria and polydipsia by 2 months of age and these features of DI progressively worsened with age [14].
  • We have recently shown that another cause of severe polyuria, chronic lithium therapy, is associated with decreased aquaporin-2 (AQP2) water channel expression (Marples, D., S. Christensen, E.I. Christensen, P.D. Ottosen, and S. Nielsen, 1995. J. Clin. Invest., 95: 1838-1845) [2].

Chemical compound and disease context of Polyuria


Biological context of Polyuria


Anatomical context of Polyuria


Gene context of Polyuria

  • These results indicate that age-related polyuria is associated with a downregulation of AQP2 and AQP3 expression in the medullary collecting duct, which is independent of vasopressin-mediated cAMP accumulation [29].
  • The present studies examined whether induction of the COX2 isoform contributes to LiCl-induced polyuria [30].
  • Lithium-associated polyuria was also seen in COX1-/- mice and was associated with increased urinary PGE(2) [30].
  • NPH3 shares with juvenile nephronophthisis (NPH1) the same disease manifestations such as polyuria, polydipsia, and secondary enuresis [31].
  • For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect [32].

Analytical, diagnostic and therapeutic context of Polyuria


  1. Captopril (SQ 14225) depresses drinking and aldosterone in rats lacking vasopressin. Henderson, I.W., McKeever, A., Kenyon, C.J. Nature (1979) [Pubmed]
  2. Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. Marples, D., Frøkiaer, J., Dørup, J., Knepper, M.A., Nielsen, S. J. Clin. Invest. (1996) [Pubmed]
  3. The mechanism of acute renal failure after uranyl nitrate. Blantz, R.C. J. Clin. Invest. (1975) [Pubmed]
  4. Relation of nocturnal polyuria of the elderly to essential hypertension. McKeigue, P.M., Reynard, J.M. Lancet (2000) [Pubmed]
  5. Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers. Tikkanen, I., Fyhrquist, F., Metsärinne, K., Leidenius, R. Lancet (1985) [Pubmed]
  6. Fatal metabolic acidosis, hyperglycemia, and coma after steroid therapy for Kearns-Sayre syndrome. Curless, R.G., Flynn, J., Bachynski, B., Gregorios, J.B., Benke, P., Cullen, R. Neurology (1986) [Pubmed]
  7. Aquaporin gene delivery to kidney. Verkman, A.S., Yang, B. Kidney Int. (2002) [Pubmed]
  8. Enuresis subtypes based on nocturnal hypercalciuria: a multicenter study. Aceto, G., Penza, R., Coccioli, M.S., Palumbo, F., Cresta, L., Cimador, M., Chiozza, M.L., Caione, P. J. Urol. (2003) [Pubmed]
  9. Lithium induced polyuria and renal vasopressin receptor density. Hensen, J., Haenelt, M., Gross, P. Nephrol. Dial. Transplant. (1996) [Pubmed]
  10. Nephrogenic diabetes insipidus presenting after head trauma. Trivedi, H.S., Nolph, K.D. American journal of nephrology. (1994) [Pubmed]
  11. Aggravation of subclinical diabetes insipidus during pregnancy. Iwasaki, Y., Oiso, Y., Kondo, K., Takagi, S., Takatsuki, K., Hasegawa, H., Ishikawa, K., Fujimura, Y., Kazeto, S., Tomita, A. N. Engl. J. Med. (1991) [Pubmed]
  12. Amelioration of polyuria by amiloride in patients receiving long-term lithium therapy. Batlle, D.C., von Riotte, A.B., Gaviria, M., Grupp, M. N. Engl. J. Med. (1985) [Pubmed]
  13. Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. Wijnholds, J., Scheffer, G.L., van der Valk, M., van der Valk, P., Beijnen, J.H., Scheper, R.J., Borst, P. J. Exp. Med. (1998) [Pubmed]
  14. A murine model of autosomal dominant neurohypophyseal diabetes insipidus reveals progressive loss of vasopressin-producing neurons. Russell, T.A., Ito, M., Ito, M., Yu, R.N., Martinson, F.A., Weiss, J., Jameson, J.L. J. Clin. Invest. (2003) [Pubmed]
  15. Studies of the mechanism of contralateral polyuria after renal artery stenosis. Galvez, O.G., Roberts, B.W., Mishkind, M.H., Bay, W.H., Ferris, T.F. J. Clin. Invest. (1977) [Pubmed]
  16. Dopamine and polyuria. Polansky, D., Eberhard, N., McGrath, R. Ann. Intern. Med. (1987) [Pubmed]
  17. Uncompensated polyuria in a mouse model of Bartter's syndrome. Takahashi, N., Chernavvsky, D.R., Gomez, R.A., Igarashi, P., Gitelman, H.J., Smithies, O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  18. Limited duration of remission of insulin dependency in children with recent overt type I diabetes treated with low-dose cyclosporin. Bougnères, P.F., Landais, P., Boisson, C., Carel, J.C., Frament, N., Boitard, C., Chaussain, J.L., Bach, J.F. Diabetes (1990) [Pubmed]
  19. Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats. Earm, J.H., Christensen, B.M., Frøkiaer, J., Marples, D., Han, J.S., Knepper, M.A., Nielsen, S. J. Am. Soc. Nephrol. (1998) [Pubmed]
  20. Dopamine-related polyuria in patients with gram-negative infection. Flis, R.S., Scoblionco, D.P., Bastl, C.P., Popovtzer, M.M. Arch. Intern. Med. (1977) [Pubmed]
  21. Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney. Akizuki, N., Uchida, S., Sasaki, S., Marumo, F. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  22. Activation of hepatic glycogen phosphorylase b in vivo by sodium sulphate in normal (Wistar) and phosphorylase b kinase-deficient (gsd/gsd) rats. Lutaya, G., Rodrigues, L.M., Griffiths, J.R. Biochem. J. (1986) [Pubmed]
  23. Lithium and the kidney: an updated review. Gitlin, M. Drug safety : an international journal of medical toxicology and drug experience. (1999) [Pubmed]
  24. Diabetes insipidus secondary to Wegener's granulomatosis: report and review of the literature. Rosete, A., Cabral, A.R., Kraus, A., Alarcón-Segovia, D. J. Rheumatol. (1991) [Pubmed]
  25. Indomethacin treatment in a patient with lithium-induced polyuria. ter Wee, P.M., van Hoek, B., Donker, A.J. Intensive care medicine. (1985) [Pubmed]
  26. Nocturnal polyuria and antidiuretic hormone levels in spinal cord injury. Szollar, S.M., Dunn, K.L., Brandt, S., Fincher, J. Archives of physical medicine and rehabilitation. (1997) [Pubmed]
  27. Attenuation of the lithium-induced diabetes-insipidus-like syndrome by amiloride in rats. Feuerstein, G., Zilberman, Y., Hemmendinger, R., Lichtenberg, D. Neuropsychobiology (1981) [Pubmed]
  28. Aldosteronoma in a dog with polyuria as the leading symptom. Rijnberk, A., Kooistra, H.S., van Vonderen, I.K., Mol, J.A., Voorhout, G., van Sluijs, F.J., IJzer, J., van den Ingh, T.S., Boer, P., Boer, W.H. Domest. Anim. Endocrinol. (2001) [Pubmed]
  29. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Preisser, L., Teillet, L., Aliotti, S., Gobin, R., Berthonaud, V., Chevalier, J., Corman, B., Verbavatz, J.M. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  30. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Rao, R., Zhang, M.Z., Zhao, M., Cai, H., Harris, R.C., Breyer, M.D., Hao, C.M. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  31. Evidence for further genetic heterogeneity in nephronophthisis. Omran, H., Häffner, K., Burth, S., Ala-Mello, S., Antignac, C., Hildebrandt, F. Nephrol. Dial. Transplant. (2001) [Pubmed]
  32. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Verkman, A.S., Yang, B., Song, Y., Manley, G.T., Ma, T. Exp. Physiol. (2000) [Pubmed]
  33. A comparison of plasma vasopressin measurements with a standard indirect test in the differential diagnosis of polyuria. Zerbe, R.L., Robertson, G.L. N. Engl. J. Med. (1981) [Pubmed]
  34. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. Marples, D., Christensen, S., Christensen, E.I., Ottosen, P.D., Nielsen, S. J. Clin. Invest. (1995) [Pubmed]
  35. Activation of hypothalamic neuronal nitric oxide synthase in lithium-induced diabetes insipidus rats. Anai, H., Ueta, Y., Serino, R., Nomura, M., Nakashima, Y., Yamashita, H. Psychoneuroendocrinology (2001) [Pubmed]
  36. Transport of inorganic phosphate in renal cortical brush-border membrane vesicles of cadmium-intoxicated rats. Ahn, D.W., Park, Y.S. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  37. Physiological basis for an animal model of the renal Fanconi syndrome: use of succinylacetone in the rat. Wyss, P.A., Boynton, S.B., Chu, J., Spencer, R.F., Roth, K.S. Clin. Sci. (1992) [Pubmed]
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