The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Fenamic acid     2-phenylazanylbenzoic acid

Synonyms: CHEMBL23832, SureCN25828, ARONIS004022, NSC-4273, Lopac-144509, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phenylanthranilic acid


High impact information on Phenylanthranilic acid


Biological context of Phenylanthranilic acid


Anatomical context of Phenylanthranilic acid


Associations of Phenylanthranilic acid with other chemical compounds


Gene context of Phenylanthranilic acid

  • In addition, the Cl channel blockers 5-nitro-2-(3-phenylpropylamino)benzoate (NPPB; 50 microM) and diphenylamine-2-carboxylic acid (DPC; 3 mM) reduced the cAMP-evoked currents by only approximately 10% [22].
  • Other chloride channel inhibitors, 4,4'-diisothiocyanatostilbene-2-2'-disulfonic acid and diphenylamine-2-carboxylic acid, also inhibited FITC-albumin uptake [23].
  • Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2 [18].
  • Taken together, our results indicate that RSMT-A5 cells possess a beta-adrenergic receptor system which controls intracellular volume and chloride content by modulating transport processes that are 1) cAMP-responsive and 2) inhibitable by the putative chloride channel blocker N-phenylanthranilic acid [24].

Analytical, diagnostic and therapeutic context of Phenylanthranilic acid

  • The oral administration of a suspension of N-phenylanthranilic acid (N-PAA), over the range of 0.5 to 2 mmol/kg for 14 consecutive days, caused a dose-related renal papillary necrosis (RPN), which involved no more than 30% of the medullary apex [25].


  1. Indirect evidence for the presence of non-specific anion channels in rabbit mandibular salivary gland acinar cells. Brown, P.D., Elliott, A.C., Lau, K.R. J. Physiol. (Lond.) (1989) [Pubmed]
  2. Adenosine induces C1- efflux in endothelial cells via a pertussis toxin-sensitive G protein. Arima, M., Ueda, S., Matsushita, S., Ozawa, T., Yamaguchi, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  3. The kinetics of papillotoxic doses of 3H-N-phenylanthranilic acid in rats. Whittingham, A., Delacruz, L., Gregg, N.J., Albores, A., Ijomah, P., Bach, P.H. Renal physiology and biochemistry. (1989) [Pubmed]
  4. Changes in the survival curve shape of E. coli cells following irradiation in the presence of uncouplers of oxidative phosphorylation. Anderson, R.F., Patel, K.B., Evans, M.D. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1985) [Pubmed]
  5. Novel pore-lining residues in CFTR that govern permeation and open-channel block. McDonough, S., Davidson, N., Lester, H.A., McCarty, N.A. Neuron (1994) [Pubmed]
  6. Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver. Hirata, K., Nathanson, M.H. Gastroenterology (2001) [Pubmed]
  7. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Kalgutkar, A.S., Crews, B.C., Rowlinson, S.W., Marnett, A.B., Kozak, K.R., Remmel, R.P., Marnett, L.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. SLC26A7 is a Cl- channel regulated by intracellular pH. Kim, K.H., Shcheynikov, N., Wang, Y., Muallem, S. J. Biol. Chem. (2005) [Pubmed]
  9. Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. Gómez-Gaviro, M.V., González-Alvaro, I., Domínguez-Jiménez, C., Peschon, J., Black, R.A., Sánchez-Madrid, F., Díaz-González, F. J. Biol. Chem. (2002) [Pubmed]
  10. Characterization of active ion transport across primary rabbit corneal epithelial cell layers (RCrECL) cultured at an air-interface. Chang-Lin, J.E., Kim, K.J., Lee, V.H. Exp. Eye Res. (2005) [Pubmed]
  11. 1H-Nuclear magnetic resonance pattern recognition studies with N-phenylanthranilic acid in the rat: time- and dose-related metabolic effects. Williams, R.E., Cottrell, L., Jacobsen, M., Bandara, L.R., Kelly, M.D., Kennedy, S., Lock, E.A. Biomarkers (2003) [Pubmed]
  12. Protein biomarkers of nephrotoxicity; a review and findings with cyclosporin A, a signal transduction kinase inhibitor and N-phenylanthranilic acid. Betton, G.R., Kenne, K., Somers, R., Marr, A. Cancer biomarkers : section A of Disease markers (2005) [Pubmed]
  13. New models of the tracheal airway define the glandular contribution to airway surface fluid and electrolyte composition. Wang, X., Zhang, Y., Amberson, A., Engelhardt, J.F. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  14. Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC. Bertog, M., Smith, D.J., Bielfeld-Ackermann, A., Bassett, J., Ferguson, D.J., Korbmacher, C., Harris, A. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  15. Diphenylamine-2-carboxylic acid (DPC), Usually an inhibitor of Cl- and non-selective cation channels, inhibits Cl-/HCO3- exchange and opens Cl- and cation conductances in rabbit gallbladder epithelium. Cremaschi, D., Porta, C., Meyer, G., Sironi, C., Garavaglia, M. Pflugers Arch. (2001) [Pubmed]
  16. Chloride ion channels are associated with adherence of lymphatic endothelial cells. Martin, D.K., Boneham, G.C., Pirie, B.L., Collin, H.B., Campbell, T.J. Microvasc. Res. (1996) [Pubmed]
  17. Diphenylamine-2-carboxylic acid potentiates the cyclic nucleotides-mediated relaxation of porcine coronary artery: possible involvement of the inhibitory effect on the efflux of cyclic nucleotides. Nakahara, T., Mitani, A., Saito, M., Sakamoto, K., Ishii, K. Vascul. Pharmacol. (2004) [Pubmed]
  18. Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes. Bauman, D.R., Rudnick, S.I., Szewczuk, L.M., Jin, Y., Gopishetty, S., Penning, T.M. Mol. Pharmacol. (2005) [Pubmed]
  19. Analysis of hyposmolarity-induced taurine efflux pathways in the bullfrog sympathetic ganglia. Sakai, S., Tosaka, T. Neurochem. Int. (1999) [Pubmed]
  20. A novel, volume-correlated Cl- conductance in marginal cells dissociated from the stria vascularis of gerbils. Takeuchi, S., Irimajiri, A. J. Membr. Biol. (1996) [Pubmed]
  21. ACTH secretion from mouse pituitary tumor cells is inhibited by loop diuretic drugs. Heisler, S. Eur. J. Pharmacol. (1991) [Pubmed]
  22. cAMP-stimulated ion currents in Xenopus oocytes expressing CFTR cRNA. Cunningham, S.A., Worrell, R.T., Benos, D.J., Frizzell, R.A. Am. J. Physiol. (1992) [Pubmed]
  23. Expression of chloride channel, ClC-5, and its role in receptor-mediated endocytosis of albumin in OK cells. Sasaki, Y., Nagai, J., Kitahara, Y., Takai, N., Murakami, T., Takano, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  24. Beta-adrenergic control of cell volume and chloride transport in an established rat submandibular cell line. He, X.J., Ship, J., Wu, X.Z., Brown, A.M., Wellner, R.B. J. Cell. Physiol. (1989) [Pubmed]
  25. The effect of N-phenylanthranilic acid-induced renal papillary necrosis on urinary acidification and renal electrolyte handling. Hardy, T.L., Bach, P.H. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
WikiGenes - Universities