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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Testicular effects of bis(2-methoxyethyl) ether in the adult male rat.

The onset of testicular pathology in the rat and possible recovery over an 8-week period were evaluated after the administration of up to 20 daily oral doses of bis(2-methoxyethyl) ether (diglyme) at 5.1 mmol/kg bw (684 mg/kg bw). Primary and secondary spermatocyte degeneration and spermatidic giant cells were observed after six to eight treatments. In addition, the testes-to-body weight ratio was significantly reduced by the tenth day of treatment and continued to be depressed eight weeks after discontinuation of the treatment. Testicular LDH-X activity, a pachytene spermatocyte marker enzyme, was significantly decreased in animals by the eighteenth day of treatment with diglyme.[1]

References

  1. Testicular effects of bis(2-methoxyethyl) ether in the adult male rat. Cheever, K.L., Weigel, W.W., Richards, D.E., Lal, J.B., Plotnick, H.B. Toxicology and industrial health. (1989) [Pubmed]
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