The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pou3f1  -  POU class 3 homeobox 1

Rattus norvegicus

Synonyms: OTF-6, Oct-6, Octamer-binding protein 6, Octamer-binding transcription factor 6, Otf-6, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pou3f1

  • Light microscopy of testes established that nodular interstitial cell hyperplasia was evident in 3 of 5 12-month-old rats and in 5 of 5 rats at 15, 18, 21, and 24 months of age [1].
  • In rats, the statistically significant increases in hepatocellular tumors and interstitial cell tumors of the testes were dose related [2].
  • Also, the rates of Leydig cell tumors of the testes (P less than 0.040) and pituitary adenomas (P less than 0.040) were statistically significant among males given the highest dose (0.6%) [3].
  • These results indicate that viable early torted testes must have their torsion corrected and be anchored in the scrotum, but if the testis is ischaemic and non-viable it should be removed to avoid damage to the contralateral testis [4].
  • Treatment of male Copenhagen F-1 rats bearing the Dunning 3327 prostate adenocarcinoma with 25 micrograms of D-Trp6-LH-RH per day for 42 days decreased the weights of both the ventral prostate and testes but had no effect on the weight of the anterior pituitary gland [5].

Psychiatry related information on Pou3f1

  • We examined locomotor activity on postnatal day 18 (PND 18), which is not influenced by perinatal androgens and juvenile play and testicular development (testes weight), which are dependent on perinatal androgen exposure, in rats whose dams consumed ethanol during pregnancy [6].
  • Males did not differ in age at the first appearance of spermatozoa in the testes but wild males were significantly older than Long--Evans and Sprague--Dawley domestic males at first copulation with a hormone-induced oestrous female [7].
  • Stereotyped behavior elicited by amphetamine in the rat: influences of the testes [8].
  • The time-response and magnitude of hCG-induced vascular changes are different in scrotal and abdominal testes [9].
  • PCS rats developed an increased urinary zinc excretion associated with weight loss, alopecia, lethargy and atrophy of the testes [10].

High impact information on Pou3f1


Chemical compound and disease context of Pou3f1


Biological context of Pou3f1


Anatomical context of Pou3f1


Associations of Pou3f1 with chemical compounds


Physical interactions of Pou3f1


Enzymatic interactions of Pou3f1


Regulatory relationships of Pou3f1

  • Recent studies further suggest that IL-6 has a role in down-regulating hormone production by endocrine organs and can negatively affect the steroidogenic capacity of both ovaries and testes [37].
  • In the present study, we have determined that Smad2 and Smad3 proteins are expressed in the postnatal testes of rats from 5 days to 60 days of age [38].
  • Western blot analysis revealed that TIP49a was abundantly expressed in testes and moderately in spleen, thymus, and lung [39].
  • The data obtained show that claudin-11 expression was inhibited in prepubertal rat testes exposed in utero to 2 and 10 mg/kg x d flutamide [40].
  • Similarly, after efferent duct ligation, the 0.9 kb SOD and PHGPX mRNA transcript levels also decreased compared to control testes (p < 0.05) [41].

Other interactions of Pou3f1

  • Northern blots indicate that Cx32 and Cx26 are typically coexpressed, messages for both having been identified in liver, kidney, intestine, lung, spleen, stomach, testes, and brain, but not heart and adult skeletal muscle [42].
  • Specific immunostaining of testes by antiserum against PHGPX appears as a fine granular brown pattern localized throughout the cytoplasm in more immature cells but is confined to the peripheral part of the cytoplasm, the nuclear membrane, and mitochondria in maturating spermatogenic cells [43].
  • Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes [44].
  • Cx33 and Cx31.1 genes exhibit a much more restricted pattern of expression; mRNAs are detected only in testes and skin, respectively [45].
  • Gene expression of FGFR-1 was developmentally regulated; expression was higher in prepubertal testes and decreased with sexual maturity [46].

Analytical, diagnostic and therapeutic context of Pou3f1

  • Northern blot analysis of total RNA and polyadenylated RNA isolated from adult rat testes showed that a proopiomelanocortin (POMC)-like messenger RNA molecule is present in these extracts [47].
  • Under these conditions, SSCs proliferated over 6 months, reconstituted long-term spermatogenesis after transplantation into recipient testes, and restored fertility to infertile recipients [48].
  • Most tissues of male rats, including blood, have very little if any ester (quantified by immunoassay as a nonpolar saponifiable metabolite), but fat and testes have sizable quantities, approximately 3 ng of testosterone equivalents per g of tissue [49].
  • In rats of the test group, a 75-mg/kg dose of EDS dissolved in dimethyl sulfoxide:water (1:3) was injected i.p. At intervals of 1, 2, 3, and 10 days after injection, two vehicle-injected control rats and three EDS-injected rats were sacrificed, and the testes were fixed by vascular perfusion [50].
  • In order to investigate the molecular basis of laminar patterning in the CNS, we have performed in situ hybridization studies of the POU homeodomain gene SCIP (also known as Tst-1 or Oct-6), which is expressed in proliferating Schwann cells in the PNS and O2A progenitor cells in the developing CNS [51].


  1. Development of Leydig cell tumors and onset of changes in the reproductive and endocrine systems of aging F344 rats. Turek, F.W., Desjardins, C. J. Natl. Cancer Inst. (1979) [Pubmed]
  2. Carcinogen bioassay and mutagenicity studies with the hypolipidemic agent gemfibrozil. Fitzgerald, J.E., Sanyer, J.L., Schardein, J.L., Lake, R.S., McGuire, E.J., de la Iglesia, F.A. J. Natl. Cancer Inst. (1981) [Pubmed]
  3. Experimental induction of hepatomas, mammary tumors, and other tumors with metronidazole in noninbred Sas:MRC(WI)BR rats. Rustia, M., Shubik, P. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. Mechanism of damage to the contralateral testis in rats with an ischaemic testis. Harrison, R.G., Lewis-Jones, D.I., Moreno de Marval, M.J., Connolly, R.C. Lancet (1981) [Pubmed]
  5. Inhibition of prostate tumor growth in two rat models by chronic administration of D-Trp6 analogue of luteinizing hormone-releasing hormone. Redding, T.W., Schally, A.V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. Prenatal ethanol exposure: effects on androgen and nonandrogen dependent behaviors and on gonadal development in male rats. Blanchard, B.A., Hannigan, J.H. Neurotoxicology and teratology. (1994) [Pubmed]
  7. Sexual maturation and fecundity of wild and domestic Norway rats (Rattus norvegicus). Clark, B.R., Price, E.O. J. Reprod. Fertil. (1981) [Pubmed]
  8. Stereotyped behavior elicited by amphetamine in the rat: influences of the testes. Beatty, W.W., Dodge, A.M., Traylor, K.L. Pharmacol. Biochem. Behav. (1982) [Pubmed]
  9. The time-response and magnitude of hCG-induced vascular changes are different in scrotal and abdominal testes. Hjertkvist, M., Bergh, A. Int. J. Androl. (1993) [Pubmed]
  10. The influence of portocaval shunting on inner ear structures. Löhle, E., Beck, C., Schölmerich, J., Baumgartner, U. Pathol. Res. Pract. (1990) [Pubmed]
  11. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Strong, T.V., Tagle, D.A., Valdes, J.M., Elmer, L.W., Boehm, K., Swaroop, M., Kaatz, K.W., Collins, F.S., Albin, R.L. Nat. Genet. (1993) [Pubmed]
  12. Rat spermatogenesis in mouse testis. Clouthier, D.E., Avarbock, M.R., Maika, S.D., Hammer, R.E., Brinster, R.L. Nature (1996) [Pubmed]
  13. Androgen-insensitive rats are defeminised by their testes. Olsen, K.L. Nature (1979) [Pubmed]
  14. The POU factor Oct-6 and Schwann cell differentiation. Jaegle, M., Mandemakers, W., Broos, L., Zwart, R., Karis, A., Visser, P., Grosveld, F., Meijer, D. Science (1996) [Pubmed]
  15. Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Waalkes, M.P., Rehm, S., Riggs, C.W., Bare, R.M., Devor, D.E., Poirier, L.A., Wenk, M.L., Henneman, J.R. Cancer Res. (1989) [Pubmed]
  16. Protection of spermatogenesis in rats from the cytotoxic procarbazine by the depot formulation of Zoladex, a gonadotropin-releasing hormone agonist. Ward, J.A., Robinson, J., Furr, B.J., Shalet, S.M., Morris, I.D. Cancer Res. (1990) [Pubmed]
  17. Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Overcash, R.G., Lindsey, J.R., Cassel, G.H., Baker, H.J. Am. J. Pathol. (1976) [Pubmed]
  18. Lipid peroxidation: a mechanism for alcohol-induced testicular injury. Rosenblum, E.R., Gavaler, J.S., Van Thiel, D.H. Free Radic. Biol. Med. (1989) [Pubmed]
  19. Progestin binding in testes from three siblings with the syndrome of male pseudohermaphroditism with testicular feminization. Dube, J.Y., Chapdelaine, P., Dionne, F.T., Cloutier, D., Tremblay, R.R. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  20. Redundancy of class III POU proteins in the oligodendrocyte lineage. Schreiber, J., Enderich, J., Sock, E., Schmidt, C., Richter-Landsberg, C., Wegner, M. J. Biol. Chem. (1997) [Pubmed]
  21. The effects of temperature and glucose on protein biosynthesis by immature (round) spermatids from rat testes. Nakamura, M., Romrell, L.J., Hall, P.F. J. Cell Biol. (1978) [Pubmed]
  22. Protective effects of analogs of luteinizing hormone-releasing hormone against x-radiation-induced testicular damage in rats. Schally, A.V., Paz-Bouza, J.I., Schlosser, J.V., Karashima, T., Debeljuk, L., Gandle, B., Sampson, M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  23. Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0. He, X., Gerrero, R., Simmons, D.M., Park, R.E., Lin, C.J., Swanson, L.W., Rosenfeld, M.G. Mol. Cell. Biol. (1991) [Pubmed]
  24. Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS. Sim, F.J., Zhao, C., Li, W.W., Lakatos, A., Franklin, R.J. Mol. Cell. Neurosci. (2002) [Pubmed]
  25. Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve. Bermingham, J.R., Shumas, S., Whisenhunt, T., Sirkowski, E.E., O'Connell, S., Scherer, S.S., Rosenfeld, M.G. J. Neurosci. (2002) [Pubmed]
  26. Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests. Warren, D.W., Dufau, M.L., Catt, K.J. Science (1982) [Pubmed]
  27. Immunohistochemical demonstration of a testicular substance related to luteinizing hormone-releasing hormone. Paull, W.K., Turkelson, C.M., Thomas, C.R., Arimura, A. Science (1981) [Pubmed]
  28. Structural and functional factors related to testicular neoplasia in feminized rats. Chung, K.W., Allison, J.E., Stanley, A.J. J. Natl. Cancer Inst. (1980) [Pubmed]
  29. Prenatal and neonatal exposure of male rat pups to cimetidine but not ranitidine adversely affects subsequent adult sexual functioning. Parker, S., Schade, R.R., Pohl, C.R., Gavaler, J.S., Van Thiel, D.H. Gastroenterology (1984) [Pubmed]
  30. Follicle-stimulating hormone stimulates estradiol-17beta synthesis in cultured Sertoli cells. Dorrington, J.H., Armstrong, D.T. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  31. Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages. Tramer, F., Micali, F., Sandri, G., Bertoni, A., Lenzi, A., Gandini, L., Panfili, E. Int. J. Androl. (2002) [Pubmed]
  32. Cellular retinol-binding protein and retinoic acid-binding protein in rat testes: effect of retinol depletion. Ong, D.E., Tsai, C.H., Chytil, F. J. Nutr. (1976) [Pubmed]
  33. Prolactin binding by testes of unilaterally cryptorchid rats: the effect of hCG, testosterone, prolactin and orchiopexy. Hochberg, Z., Amit, T., Youdim, M.B., Bar-Maor, J.A. Acta Endocrinol. (1983) [Pubmed]
  34. Metallothionein-like cadmium binding protein in rat testes administered with cadmium and selenium. Ohta, H., Seki, Y., Imamiya, S. Bulletin of environmental contamination and toxicology. (1988) [Pubmed]
  35. Rat testes interstitial cell nuclei exhibit three distinct receptors for retinoic acid. Cope, F.O., Knox, K.L., Hall, R.C. Experientia (1984) [Pubmed]
  36. Specific mRNAs in Sertoli and germinal cells of testes from stage synchronized rats. Morales, C.R., Alcivar, A.A., Hecht, N.B., Griswold, M.D. Mol. Endocrinol. (1989) [Pubmed]
  37. The expression of interleukin-6 in the pregnant rat corpus luteum and its regulation by progesterone and glucocorticoid. Telleria, C.M., Ou, J., Sugino, N., Ferguson, S., Gibori, G. Endocrinology (1998) [Pubmed]
  38. Developmental and stage-specific expression of Smad2 and Smad3 in rat testis. Xu, J., Beyer, A.R., Walker, W.H., McGee, E.A. J. Androl. (2003) [Pubmed]
  39. A rat RuvB-like protein, TIP49a, is a germ cell-enriched novel DNA helicase. Makino, Y., Kanemaki, M., Kurokawa, Y., Koji, T., Tamura, T. J. Biol. Chem. (1999) [Pubmed]
  40. Androgens and postmeiotic germ cells regulate claudin-11 expression in rat Sertoli cells. Florin, A., Maire, M., Bozec, A., Hellani, A., Chater, S., Bars, R., Chuzel, F., Benahmed, M. Endocrinology (2005) [Pubmed]
  41. Cu/Zn superoxide dismutase, catalase and glutathione peroxidase mRNA expression in the rat testis after surgical cryptorchidism and efferent duct ligation. Zini, A., Schlegel, P.N. J. Urol. (1997) [Pubmed]
  42. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. Zhang, J.T., Nicholson, B.J. J. Cell Biol. (1989) [Pubmed]
  43. Phospholipid hydroperoxide glutathione peroxidase of rat testis. Gonadotropin dependence and immunocytochemical identification. Roveri, A., Casasco, A., Maiorino, M., Dalan, P., Calligaro, A., Ursini, F. J. Biol. Chem. (1992) [Pubmed]
  44. Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes. Rublevskaya, I., Maines, M.D. J. Biol. Chem. (1994) [Pubmed]
  45. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger, J.A., Bruzzone, R., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Paul, D.L. J. Biol. Chem. (1992) [Pubmed]
  46. Fibroblast growth factor receptor type 1 expression during rat testicular development and its regulation in cultured Sertoli cells. Le Magueresse-Battistoni, B., Wolff, J., Morera, A.M., Benahmed, M. Endocrinology (1994) [Pubmed]
  47. Characterization and localization of proopiomelanocortin messenger RNA in the adult rat testis. Pintar, J.E., Schachter, B.S., Herman, A.B., Durgerian, S., Krieger, D.T. Science (1984) [Pubmed]
  48. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Kubota, H., Avarbock, M.R., Brinster, R.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  49. Long-lived testosterone esters in the rat. Borg, W., Shackleton, C.H., Pahuja, S.L., Hochberg, R.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  50. Necrotizing effect of ethanedimethanesulfonate on spontaneously occurring Leydig cell tumors in old F344 rats. Morii, S., Naka, Y., Inui, T., Shintani, H. Cancer Res. (1988) [Pubmed]
  51. Regulation of the POU domain gene SCIP during cerebral cortical development. Frantz, G.D., Bohner, A.P., Akers, R.M., McConnell, S.K. J. Neurosci. (1994) [Pubmed]
WikiGenes - Universities