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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Vacor inhibits insulin release from islets in vitro.

It has been reported that Vacor, a rodenticide containing N-3-pyridylmethyl-N'-p-nitrophenyl urea, causes insulin-dependent diabetes mellitus. The pathomechanism of Vacor-induced diabetes mellitus has not been clarified yet. The effect of Vacor, therefore, was studied in terms of insulin release from isolated rat pancreatic islets. Vacor suppressed glucose-stimulated insulin release, but did not affect the insulin release induced by theophylline or 12-o-tetra-decanoylphorbol 13-acetate. It is suspected that the suppression of insulin release from pancreatic islets by Vacor may contribute to the pathogenesis of Vacor-induced diabetes mellitus and that this suppression might not be related to cAMP and C-kinase.[1]


  1. Vacor inhibits insulin release from islets in vitro. Taniguchi, H., Yamashiro, Y., Chung, M.Y., Hara, Y., Ishihara, K., Ejiri, K., Baba, S. J. Endocrinol. Invest. (1989) [Pubmed]
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