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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A new family of 2-hydroxyacid dehydrogenases.

The NADH-dependent hydroxypyruvate reductase from cucumber and the pdxB gene product of E. coli display significant homology to E. coli D-3-phosphoglycerate dehydrogenase. In contrast, these proteins do not display much similarity with other oxidoreductases or with other 2-hydroxyacid dehydrogenases in particular. On the basis of their relatedness and the structure of their substrates, these three enzymes constitute a new family of 2-hydroxyacid dehydrogenases distinct from malate and lactate dehydrogenase.[1]


  1. A new family of 2-hydroxyacid dehydrogenases. Grant, G.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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