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Gene Review

serA  -  D-3-phosphoglycerate dehydrogenase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2909, JW2880
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Disease relevance of serA


High impact information on serA


Chemical compound and disease context of serA


Associations of serA with chemical compounds

  • Similarity searches of protein data bases revealed a significant number of amino acid matches between the pdxB gene product and D-3-phosphoglycerate dehydrogenase, which is encoded by serA and catalyzes the first step in the phosphorylated pathway of serine biosynthesis [13].
  • A previously described mutation in a leucine-responsive trans-acting factor, LivR (J. J. Anderson, S. C. Quay, and D. L. Oxender, J. Bacteriol. 126:80-90, 1976), resulted in constitutively repressed expression from the tdh promoter and constitutively induced expression from the serA promoter [10].

Analytical, diagnostic and therapeutic context of serA


  1. Mutant of Escherichia coli K-12 with defective phosphorylation of two periplasmic transport proteins. Celis, R.T. J. Biol. Chem. (1990) [Pubmed]
  2. The organization of the Bacillus subtilis 168 chromosome region between the spoVA and serA genetic loci, based on sequence data. Sorokin, A., Zumstein, E., Azevedo, V., Ehrlich, S.D., Serror, P. Mol. Microbiol. (1993) [Pubmed]
  3. Evolutionary relationship of NAD(+)-dependent D-lactate dehydrogenase: comparison of primary structure of 2-hydroxy acid dehydrogenases. Kochhar, S., Hunziker, P.E., Leong-Morgenthaler, P., Hottinger, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  4. Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits. Dey, S., Grant, G.A., Sacchettini, J.C. J. Biol. Chem. (2005) [Pubmed]
  5. Hybrid tetramers reveal elements of cooperativity in Escherichia coli D-3-phosphoglycerate dehydrogenase. Grant, G.A., Hu, Z., Xu, X.L. J. Biol. Chem. (2003) [Pubmed]
  6. The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Cross-linking adjacent regulatory domains with engineered disulfides mimics effector binding. Al-Rabiee, R., Lee, E.J., Grant, G.A. J. Biol. Chem. (1996) [Pubmed]
  7. The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase. Tobey, K.L., Grant, G.A. J. Biol. Chem. (1986) [Pubmed]
  8. Phosphate ion partially relieves the cooperativity of effector binding in D-3-phosphoglycerate dehydrogenase without altering the cooperativity of inhibition. Grant, G.A., Xu, X.L., Hu, Z., Purvis, A.R. Biochemistry (1999) [Pubmed]
  9. Cloning and analysis of gene clusters for production of the Escherichia coli K10 and K54 antigens: identification of a new group of serA-linked capsule gene clusters. Pearce, R., Roberts, I.S. J. Bacteriol. (1995) [Pubmed]
  10. The tdh and serA operons of Escherichia coli: mutational analysis of the regulatory elements of leucine-responsive genes. Rex, J.H., Aronson, B.D., Somerville, R.L. J. Bacteriol. (1991) [Pubmed]
  11. Developmental regulation of the gene for formate dehydrogenase in Neurospora crassa. Chow, C.M., RajBhandary, U.L. J. Bacteriol. (1993) [Pubmed]
  12. A new family of 2-hydroxyacid dehydrogenases. Grant, G.A. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  13. Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12. Schoenlein, P.V., Roa, B.B., Winkler, M.E. J. Bacteriol. (1989) [Pubmed]
  14. Sequence analysis of the Bacillus subtilis chromosome region between the serA and kdg loci cloned in a yeast artificial chromosome. Sorokin, A., Azevedo, V., Zumstein, E., Galleron, N., Ehrlich, S.D., Serror, P. Microbiology (Reading, Engl.) (1996) [Pubmed]
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